Results 21 to 30 of about 288,351 (166)

Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension

Biomolecules & Biomedicine, 2011
Endothelin 1 (ET-1) is vasoactive peptide that acts via ET-A receptors coupling inducing vascular smooth muscle cell proliferation and contraction. ET-1 is involved in the development and maintenance of hypertension.
Farid Ljuca, Gorazd Drevenšek, Enver Zerem   +2 more
doaj   +1 more source

Effects of Homocysteine and Hyperglycemia on the Proliferation of Aortic Vascular Smooth Muscle Cells of Obese Type 2 Diabetes Rat

Annals of Geriatric Medicine and Research, 2017
Background : The aim of this study was to investigate the role of homocysteine on the proliferation of rat aortic vascular smooth muscle cells (VSMCs) by measuring mitogen-activated protein (MAP) kinase under hyperglycemic conditions.
Hyung Joon Yoo, Sung Hoon Yu, Young Jung Cho, Hong Woo Nam, Dong Hyun Kang   +4 more
doaj   +1 more source

Isopanduratin A Inhibits Tumor Necrosis Factor (TNF)-α-Induced Nuclear Factor κB Signaling Pathway by Promoting Extracellular Signal-Regulated Kinase-Dependent Ectodomain Shedding of TNF Receptor 1 in Human Lung Adenocarcinoma A549 Cells

BioChem, 2021
Tumor necrosis factor α (TNF-α) induces the nuclear factor κB (NF-κB) signaling pathway via TNF receptor 1 (TNF-R1). We recently reported that isopanduratin A inhibited the TNF-α-induced NF-κB signaling pathway in human lung adenocarcinoma A549 cells. In
Chihiro Moriwaki, Riho Tanigaki, Yasunobu Miyake, Nghia Trong Vo, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Van Do, Hai Xuan Nguyen, Takao Kataoka   +8 more
doaj   +1 more source

Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells.

Journal of Biological Chemistry, 1994
In the renal medulla during antidiuresis, the extracellular fluid becomes hyperosmotic. Madin-Darby canine kidney (MDCK) epithelial cells adapt in hyperosmotic conditions and serve as a useful tissue culture model for cellular responses to hyperosmolality.
Y, Terada, K, Tomita, M K, Homma, H, Nonoguchi, T, Yang, T, Yamada, Y, Yuasa, E G, Krebs, S, Sasaki, F, Marumo   +9 more
openaire   +2 more sources

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2 [PDF]

European Journal of Biochemistry, 1993
Mitogen‐activated protein‐kinase (MAP) kinase‐activated protein kinases 1 and 2 (MAPKAP kinase‐1, MAPKAP kinase‐2), were found to phosphorylate bacterially expressed human tyrosine hydroxylase in vitro at comparable rates to other proteins thought to be physiological substrates of these protein kinases.
Sutherland, Calum, Alterio, Janine, Campbell, David G., Le Bourdellès, Béatrice, Mallet, Jacques, Haavik, Jan, Cohen, Philip   +6 more
openaire   +3 more sources

Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells

Journal of Lipid Research, 2001
This study was conducted on human Jurkat T cell lines to elucidate the role of EPA and DHA, n-3 PUFA, in the modulation of two mitogen-activated protein (MAP) kinases, that is, extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2).
Anne Denys, Aziz Hichami, Naim Akhtar Khan   +2 more
doaj   +1 more source

Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. [PDF]

PLoS ONE, 2013
Rupture of an atherosclerotic plaque is a key event in the development of cardiovascular disorders, in which matrix metalloproteinase-1 (MMP-1) plays a crucial role by degradation of extracellular matrix resulting in plaque instability.
Akinori Tokito, Michihisa Jougasaki, Tomoko Ichiki, Shuichi Hamasaki   +3 more
doaj   +1 more source

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

The EMBO journal, 1996
The Tpl-2 protein serine/threonine kinase was originally identified, in a C-terminally deleted form, as the product of an oncogene associated with the progression of Moloney murine leukemia virus-induced T cell lymphomas in rats. The kinase domain of Tpl-2 is homologous to the Saccharomyces cerevisiae gene product, STE11, which encodes a MAP kinase ...
A, Salmeron, T B, Ahmad, G W, Carlile, D, Pappin, R P, Narsimhan, S C, Ley   +5 more
openaire   +3 more sources

Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. [PDF]

PLoS ONE, 2011
Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Docosahexaenoic acid (DHA), a representative ω-3 polyunsaturated fatty acid, has been reported to possess anti-inflammatory and chemopreventive ...
Mostafizur Rahman, Joydeb Kumar Kundu, Jun-Wan Shin, Hye-Kyung Na, Young-Joon Surh   +4 more
doaj   +1 more source

MAP kinase-interacting kinase 1 (MNK1) plays as a tumor suppressor in bladder cancer

Translational Cancer Research, 2020
MAP kinase-interacting kinase 1 (MNK1) has been reported to be over-expressed in several cancers, however, its expression level and biological function in bladder cancer (BCa) remains unclear.Besides analyzing human publicly available dataset, we used quantitative real-time PCR, western blotting and immunohistochemistry to evaluate the expression of ...
Chen, Zhuangfei, Xiao, Kanghua, Zhang, Hao, Liu, Cundong, Yang, Jiankun, Liang, Haitao, Lin, Zhijun, Qin, Zike, Chen, Mingkun, Ye, Yunlin   +9 more
openaire   +2 more sources