Results 41 to 50 of about 288,351 (166)

Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
Inappropriate activation of innate immune responses in intestinal epithelial cells underlies the pathophysiology of inflammatory disorders of the intestine.
Hilary K. Cheesman, Rhonda L. Feinbaum, Jose Thekkiniath, Robert H. Dowen, Annie L. Conery, Read Pukkila-Worley   +5 more
doaj   +1 more source

Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

Frontiers in Immunology, 2022
Lung cancer poses a serious threat to human health and has recently been tagged the most common malignant disease with the highest incidence and mortality rate.
Bashir Lawal, Bashir Lawal, Alexander T. H. Wu, Alexander T. H. Wu, Alexander T. H. Wu, Alexander T. H. Wu, Hsu-Shan Huang, Hsu-Shan Huang, Hsu-Shan Huang, Hsu-Shan Huang, Hsu-Shan Huang   +10 more
doaj   +1 more source

Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1) [PDF]

Journal of Cellular Biochemistry, 2015
ABSTRACTPreviously, we showed that Mekk1 translocates to the nucleus, interacts with tumor suppressor protein p53, and co‐represses PKD1 transcription via an atypical p53 binding site on the minimal PKD1 promoter (JBC 285:38,818–38,831, 2010). In this study, we report the mechanisms of Mekk1 nuclear transport and p53 binding.
Elizabeth, Chipps, April, Protzman, M Zubayed, Muhi, Shoko, Ando, James P, Calvet, M Rafiq, Islam   +5 more
openaire   +2 more sources

Signaling pathways in cerebral vasospasm

Brazilian Neurosurgery, 2011
Cerebral vasospasm is a deadly complication following the rupture of intracranial aneurysms. One new development in the experimental treatment of cerebral vasospasm is the looming target of signaling pathways.
Flávio Ramalho Romero, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira   +2 more
doaj   +1 more source

Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. [PDF]

PLoS ONE, 2009
Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway.
Anne N Shemon, Eva M Eves, Matthew C Clark, Gary Heil, Alexey Granovsky, Lingchun Zeng, Akira Imamoto, Shohei Koide, Marsha Rich Rosner   +8 more
doaj   +1 more source

MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans [PDF]

Molecular Cell, 1999
In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM ...
Shin, Tae Ho, Yasuda, Jun, Rocheleau, Christian Ernest, Lin, Rueyling, Soto, Martha C., Bei, Yanxia, Davis, Roger J., Mello, Craig C.   +7 more
openaire   +3 more sources

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity [PDF]

Cell Metabolism, 2006
The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes and obesity. The MAPKs are inactivated by MAPK phosphatases (MKPs) either in the cytosol or nucleus. Here we show that mice lacking the nuclear-localized MKP, MKP-1 (mkp-1(-/-)), have enhanced Erk, p38 MAPK and c-Jun NH(2)-terminal kinase (JNK) activities ...
Wu, J. Julie, Roth, Rachel J., Anderson, Ethan J., Hong, Eun-Gyoung, Lee, Mi-Kyung, Choi, Cheol Soo, Neufer, P. Darrell, Shulman, Gerald I., Kim, Jason K., Bennett, Anton M.   +9 more
openaire   +2 more sources

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

Molecules, 2021
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate soluble ...
Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach   +16 more
doaj   +1 more source

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

Journal of Inflammation, 2006
Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
doaj   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source