Results 221 to 230 of about 222,900 (341)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Selective inhibition of ATPase activity during contraction alters the activation of p38 MAP kinase isoforms in skeletal muscle

, 2013
Jeffrey J. Brault, Natalie M. Pizzimenti, John N. Dentel, Robert W. Wiseman   +3 more
openalex   +1 more source

Activation of mitogen activated protein (MAP) kinases by vanadate is independent of insulin receptor autophosphorylation [PDF]

, 1994
F. D'ONOFRIO, Minh Quynh Uyen Le, Jean-Louis Chiasson, Ashok K. Srivastava   +3 more
openalex   +1 more source

MAPK Pathways Coordinate Stress Adaptation by Mobilizing Specialized Gene Modules in Entomopathogenic Fungus <i>Beauveria bassiana</i>. [PDF]

J Fungi (Basel)
Huang S, Fan H, Zhu C, Li M, Liu L, Bai M, Zhou Y, Zhang Y.   +7 more
europepmc   +1 more source

MAP kinase kinase kinase 12 (MAP3K12; DLK) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival [PDF]

, 2019
Chih-Shia Lee, Liam C. Lee, Tina L. Yuan, Sirisha Chakka, Christof Fellmann, Scott W. Lowe, Natasha J. Caplen, Frank McCormick, Ji Luo   +8 more
openalex   +1 more source

Structural Rationalization of IPMK Inhibitor Potency. [PDF]

J Med Chem
Wang H, Shears SB, Blind RD.
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Inhibitors supercharge kinase turnover through native proteolytic circuits. [PDF]

Nature
Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE.   +29 more
europepmc   +1 more source