MPM-2 epitope sequence is not sufficient for recognition and phosphorylation by ME kinase-H [PDF]
, 1997 Monoclonal antibody MPM-2 recognizes a large family of mitotic phosphoproteins in a phosphorylation-dependent manner. The antigenic phosphoepitope, designated the MPM-2 epitope, putatively consists of hydrophobic residue-Thr/Ser-Pro-hydrophobic residue ...
Ashorn, Cheryl L +4 more
core +1 more source
Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK [PDF]
Journal of Biological Chemistry, 2001 The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway.
Makoto Adachi +2 more
openaire +3 more sources
An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
core +1 more source
BWMK1, a Novel MAP Kinase Induced by Fungal Infection and Mechanical Wounding in Rice
Molecular Plant-Microbe Interactions, 1999 The activation of the mitogen-activated protein (MAP) kinases by different environmental stresses has been previously observed in several dicot plant species. Here, we report the isolation of a novel MAP kinase in rice that is induced during infection by
Chaozu He +3 more
doaj +1 more source
Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*)
Journal of Biological Chemistry, 1996 Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain enzymatic activity. This activation is carried out by a family of enzymes known as MAP kinase kinases (MKKs or MEKs). It appears that
Jiahuai Han +5 more
semanticscholar +1 more source
Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]
, 2017 In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Bose, Ron, Kumar, Runjun D
core +2 more sources
Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage
Cell Reports, 2013 DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors (TFs) are not well ...
Eric J. Jaehnig +4 more
doaj +1 more source
Zoonoses, 2023 This study was aimed at investigating the immunoregulatory effects of trypanosomal lipophosphoglycan (LPG) anchored to trypanosome membranes, including the formation of neutrophil extracellular traps (NETs) and neutrophil cytokine release after parasite ...
Kai Zhang +7 more
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources
Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase [PDF]
Journal of Biological Chemistry, 1999 Internalization of activated receptors from the plasma membrane has been implicated in the activation of mitogen-activated protein (MAP) kinase. However, the mechanism whereby membrane trafficking may regulate mitogenic signaling remains unclear.
Onno Kranenburg +2 more
openaire +3 more sources