Results 1 to 10 of about 1,192,359 (196)

Systems biology analysis of G protein and MAP kinase signaling in yeast [PDF]

Oncogene, 2007
Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the treatment of human disease.
Marcelo Behar, Nan Hao, Henrik G. Dohlman, Timothy C. Elston   +3 more
openaire   +4 more sources

Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System [PDF]

Journal of Neuroscience, 2005
In the present study, we examined the role of the auditory thalamus [medial division of the medial geniculate nucleus and the adjacent posterior intralaminar nucleus (MGm/PIN)] in auditory pavlovian fear conditioning using pharmacological manipulation of intracellular signaling pathways.
Glenn E. Schafe, Valérie Doyère, Valérie Doyère, Jacek Debiec, Joseph E. LeDoux, Annemieke M. Apergis-Schoute   +5 more
openaire   +5 more sources

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

J Biol Chem 285,(2), 2010, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +4 more sources

Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder

Seminars in Cell & Developmental Biology, 2011
Understanding the mechanisms of drug action has been the primary focus for pharmacological researchers, traditionally using rodent models. However, non-sentient model systems are now increasingly being used as an alternative approach to better understand drug action or targets.
Robin S.B. Williams, Marthe H.R. Ludtmann, Katrina Boeckeler   +2 more
openaire   +4 more sources

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]

PLoS Medicine, 2006
BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore, Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Jones, Toni L, Rosengren, Sanna, Sorkin, Linda, Svensson, Camille I   +7 more
core   +5 more sources

Effects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats

Drug and Chemical Toxicology, 2021
Effects of Caffeic acid phenethyl ester (CAPE) and/or PD98059 (PD) on the gene expression of Caveolin-1 (CAV1) and reduced glutathione (GSH), malondialdehyde (MDA), copper-zinc superoxide dismutase (CuZn-SOD), and catalase (CAT) enzyme activities were investigated in an experimental chronic renal failure model in rats.
Ciğremiş, Yilmaz, Özen, Hasan, Durhan, Merve, Tunç, Selahattin, Köse, Evren   +4 more
openaire   +5 more sources

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory [PDF]

Journal of Neurochemistry, 2001
The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies, was originally discovered as a critical regulator of cell division and differentiation. As further details of this signaling cascade were worked out, it became clear that the MAPK cascade is in fact a prototype for a family of signaling cascades that share the motif ...
J. David Sweatt
openaire   +4 more sources

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]

, 2012
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core   +3 more sources

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase [PDF]

, 2006
ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes.
King, Victoria, Millson, Stefan H, Mollapour, Medhi, Nuttall, James M, Pearl, Laurence H, Piper, Peter W, Prodromou, Chrisostomos, Truman, Andrew W   +7 more
core   +2 more sources