Results 1 to 10 of about 328,405 (155)
Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System [PDF]
Journal of Neuroscience, 2005 In the present study, we examined the role of the auditory thalamus [medial division of the medial geniculate nucleus and the adjacent posterior intralaminar nucleus (MGm/PIN)] in auditory pavlovian fear conditioning using pharmacological manipulation of intracellular signaling pathways.
Annemieke M. Apergis-Schoute
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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory [PDF]
Journal of Neurochemistry, 2001 The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies, was originally discovered as a critical regulator of cell division and differentiation. As further details of this signaling cascade were worked out, it became clear that the MAPK cascade is in fact a prototype for a family of signaling cascades that share the motif ...
J. David Sweatt
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Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
PLoS Medicine, 2006 Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
David L Boyle +7 more
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Systems biology analysis of G protein and MAP kinase signaling in yeast [PDF]
Oncogene, 2007 Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the treatment of human disease.
Nan Hao +3 more
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Seminars in Cell & Developmental Biology, 2010 Understanding the mechanisms of drug action has been the primary focus for pharmacological researchers, traditionally using rodent models. However, non-sentient model systems are now increasingly being used as an alternative approach to better understand drug action or targets.
Marthe H. R. Ludtmann +2 more
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Drug and Chemical Toxicology, 2021 Effects of Caffeic acid phenethyl ester (CAPE) and/or PD98059 (PD) on the gene expression of Caveolin-1 (CAV1) and reduced glutathione (GSH), malondialdehyde (MDA), copper-zinc superoxide dismutase (CuZn-SOD), and catalase (CAT) enzyme activities were investigated in an experimental chronic renal failure model in rats.
Yılmaz Çiğremiş +4 more
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Studies on MAP Kinase Signaling in the Immune System
, 2010 The primary function of the immune system is to protect the organism from invading pathogens. In response to pathogen invasion, multiple signaling pathways are activated in immune cells, leading to diverse immune defense mechanisms. Chief among these pathways is the activation of MAPKs, which are crucial for transcriptional and nontranscriptional ...
Hongbo Chi, Richard A. Flavell
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Neobavaisoflavone ameliorates LPS-induced RAW264.7 cell inflammations by suppressing the activation of NF-κB and MAPKs signaling pathways [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Neobavaisoflavone (NBIF) is an isoflavone isolated from Psoralea corylifolia L. It can effectively regulate the redox state as a natural anti-oxidant and show some anti-inflammatory activity.
Qing Yuan +8 more
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Nimodipine promotes neurite outgrowth and protects against neurotoxicity in PC12 cells [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Nimodipine is an L-type voltage-dependent calcium channel (VDCC) antagonist. However, the actions of nimodipine except calcium blocking are poorly understood. This study aimed to investigate the effect of nimodipine on neurite outgrowth and
Miduki Kusakabe, Yasushi Hasegawa
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