Results 21 to 30 of about 322,191 (274)

Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder

Seminars in Cell & Developmental Biology, 2011
Understanding the mechanisms of drug action has been the primary focus for pharmacological researchers, traditionally using rodent models. However, non-sentient model systems are now increasingly being used as an alternative approach to better understand drug action or targets.
Ludtmann, Marthe H.R., Boeckeler, Katrina, Williams, Robin S.B.   +2 more
openaire   +2 more sources

Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand-dependent activation of defense responses [PDF]

, 2015
Plant plasma membrane localized pattern recognition receptors (PRRs) detect extracellular pathogen-associated molecules. PRRs such as Arabidopsis EFR and rice XA21 are taxonomically restricted and are absent from most plant genomes.
A Afroz, A Daudi, A Heese, A Keller, AP Macho, AP Macho, Arsalan Daudi, B Schulze, B Schwessinger, B Schwessinger, Benjamin Schwessinger, BM Lee, BMJ Mendes, C Segonzac, C Zipfel, C-J Park, C-J Park, Christopher Daum, Christopher J. Petzold, CJ Park, CJ Park, CJ Park, CR Clarke, Cyril Zipfel, D Chinchilla, D Chinchilla, D Chinchilla, D Kim, D Lu, Deling Ruan, DJ McCarthy, E Fradin, F Lu, G Felix, G Kunze, G Qian, H Haweker, H Hirai, H Ochiai, H Schoonbeek, H Wickham, H Zhang, J Li, J Li, J Monaghan, J Zhang, JD Jones, JF González, JN Tripathi, Joshua L. Heazlewood, K Kishimoto, L Trdá, LA Boyd, M Albert, M Boudsocq, M Boudsocq, M Lopez-Gomez, M Roux, Mansi Chovatia, MD Robinson, MS Chern, N Holton, Nicolas Holton, Nicolas Thomas, O Bahar, Ofir Bahar, P Schulze-Lefert, Pamela C. Ronald, Patrick E. Canlas, PC Ronald, R Cai, R De Jonge, R Lozano-Durán, R Sharma, R Takai, Rita Kuo, S Lacombe, S Tan, S Wang, S Zuo, SH Spoel, SL Salzberg, ST Chisholm, SW Lee, T Boller, T Furukawa, T Maekawa, T Nakagawa, T Xiang, V Nekrasov, Vasanth R. Singan, Vladimir Nekrasov, W Liu, Wenbo Ma, WY Song, WY Song, X Chen, X Chen, X Chen, X Chen, Y Ao, Y Hiei, Y Jiang, Y Kadota, Y Katsuragi, Y Kawahara, Y Kawano, Y Peng, Y Saijo, Y Saijo, Y Xiang, YS Seo, YS Wang   +112 more
core   +5 more sources

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Understanding intellectual disability through RASopathies [PDF]

, 2014
Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the
Pagani, Mario Rafael, San Martín, Alvaro   +1 more
core   +1 more source

CRAF R391W is a melanoma driver oncogene. [PDF]

, 2016
Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad, Avramis, Earl, Chmielowski, Bartosz, Friedman, Michael, Graeber, Thomas G, Lassen, Amanda, Le, Allison, Lomova, Anastasia, Ng, Charles, Ribas, Antoni, Titz, Bjoern, Tsoi, Jennifer   +11 more
core   +3 more sources

BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.

PLoS ONE, 2008
Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking.
Joseph H Jeong, Zhenxiong Wang, Alexander S Guimaraes, Xuesong Ouyang, Jose L Figueiredo, Zhihu Ding, Shan Jiang, Isil Guney, Gyeong Hoon Kang, Eyoung Shin, William C Hahn, Massimo F Loda, Cory Abate-Shen, Ralph Weissleder, Lynda Chin   +14 more
doaj   +1 more source

Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors

Molecules, 2021
RET (rearranged during transfection) kinase, one of the receptor tyrosine kinases, plays a crucial role in the development of the human nervous system.
Swapnil P. Bhujbal, Seketoulie Keretsu, Seung Joo Cho   +2 more
doaj   +1 more source

Loss-of-function analysis of EphA receptors in retinotectal mapping [PDF]

, 2004
Peer reviewedPublisher ...
DeChiara, Thomas M., Feldheim, David A., Flanagan, John G., Gale, Nicholas W., Nakamoto, Masaru, Osterfield, Miriam, Rohatgi, Rajat, Yancopoulos, George D.   +7 more
core   +1 more source

Interaction Analysis of a Two-Component System Using Nanodiscs. [PDF]

PLoS ONE, 2016
Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein.
Patrick Hörnschemeyer, Viktoria Liss, Ralf Heermann, Kirsten Jung, Sabine Hunke   +4 more
doaj   +1 more source

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]

, 2015
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E, Ley, SC, Schweighoffer, E, Tybulewicz, VL   +3 more
core   +1 more source