Results 31 to 40 of about 1,192,359 (196)

Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors

Molecules, 2021
RET (rearranged during transfection) kinase, one of the receptor tyrosine kinases, plays a crucial role in the development of the human nervous system.
Swapnil P. Bhujbal, Seketoulie Keretsu, Seung Joo Cho   +2 more
doaj   +1 more source

Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand-dependent activation of defense responses [PDF]

, 2015
Plant plasma membrane localized pattern recognition receptors (PRRs) detect extracellular pathogen-associated molecules. PRRs such as Arabidopsis EFR and rice XA21 are taxonomically restricted and are absent from most plant genomes.
A Afroz, A Daudi, A Heese, A Keller, AP Macho, AP Macho, Arsalan Daudi, B Schulze, B Schwessinger, B Schwessinger, Benjamin Schwessinger, BM Lee, BMJ Mendes, C Segonzac, C Zipfel, C-J Park, C-J Park, Christopher Daum, Christopher J. Petzold, CJ Park, CJ Park, CJ Park, CR Clarke, Cyril Zipfel, D Chinchilla, D Chinchilla, D Chinchilla, D Kim, D Lu, Deling Ruan, DJ McCarthy, E Fradin, F Lu, G Felix, G Kunze, G Qian, H Haweker, H Hirai, H Ochiai, H Schoonbeek, H Wickham, H Zhang, J Li, J Li, J Monaghan, J Zhang, JD Jones, JF González, JN Tripathi, Joshua L. Heazlewood, K Kishimoto, L Trdá, LA Boyd, M Albert, M Boudsocq, M Boudsocq, M Lopez-Gomez, M Roux, Mansi Chovatia, MD Robinson, MS Chern, N Holton, Nicolas Holton, Nicolas Thomas, O Bahar, Ofir Bahar, P Schulze-Lefert, Pamela C. Ronald, Patrick E. Canlas, PC Ronald, R Cai, R De Jonge, R Lozano-Durán, R Sharma, R Takai, Rita Kuo, S Lacombe, S Tan, S Wang, S Zuo, SH Spoel, SL Salzberg, ST Chisholm, SW Lee, T Boller, T Furukawa, T Maekawa, T Nakagawa, T Xiang, V Nekrasov, Vasanth R. Singan, Vladimir Nekrasov, W Liu, Wenbo Ma, WY Song, WY Song, X Chen, X Chen, X Chen, X Chen, Y Ao, Y Hiei, Y Jiang, Y Kadota, Y Katsuragi, Y Kawahara, Y Kawano, Y Peng, Y Saijo, Y Saijo, Y Xiang, YS Seo, YS Wang   +112 more
core   +5 more sources

Interaction Analysis of a Two-Component System Using Nanodiscs. [PDF]

PLoS ONE, 2016
Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein.
Patrick Hörnschemeyer, Viktoria Liss, Ralf Heermann, Kirsten Jung, Sabine Hunke   +4 more
doaj   +1 more source

Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae. [PDF]

, 2014
BackgroundSusceptibility to Plasmodium infection in Anopheles gambiae has been proposed to result from naturally occurring polymorphisms that alter the strength of endogenous innate defenses.
Anishchenko, Michael, Brault, Aaron C, Brenton, Ashley A, Cheung, Kong, Luckhart, Shirley, Souvannaseng, Lattha   +5 more
core   +3 more sources

Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations [PDF]

, 2020
To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study,
Cassidy, Keith, Himes, Benjamin A., Luthey-Schulten, Z., Ma, Jun, Parkinson, John S., Stansfeld, Phillip J., Sun, Dapeng, Zhang, Peijun, Zhao, Gongpu   +8 more
core   +1 more source

Parallel implementation of stochastic simulation for large-scale cellular processes [PDF]

, 2005
Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional ...
Burrage, K., Tian, T.
core   +2 more sources

Dopaminergic dysregulation in prefrontal cortex of rhesus monkeys following cocaine self-administration

Frontiers in Psychiatry, 2013
Chronic cocaine administration regulates the expression of several proteins related to dopaminergic signaling and synaptic function in the mesocorticolimbic pathway, including the prefrontal cortex.
Scot eMcIntosh, Leonard H Howell, Leonard H Howell, Scott E Hemby   +3 more
doaj   +1 more source

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

Antioxidants, 2021
ROS (reactive oxygen species) are produced via the noncomplete reduction in molecular oxygen in the mitochondria of higher organisms. The produced ROS are placed in various cell compartments, such as the mitochondria, cytoplasm, and endoplasmic reticulum.
Abdelhakim Bouyahya, Naoual El Menyiy, Loubna Oumeslakht, Aicha El Allam, Abdelaali Balahbib, Abdur Rauf, Naveed Muhammad, Elena Kuznetsova, Marina Derkho, Muthu Thiruvengadam, Mohammad Ali Shariati, Nasreddine El Omari   +11 more
doaj   +1 more source

When kinases meet mathematics: the systems biology of MAPK signalling [PDF]

, 2005
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified ...
Becskei, Becskei, Bhalla, Black, Boldt, Brightman, Butcher, Chapman, Cho, Corbit, David Gilbert, Dhillon, Dhillon, Douville, Eblen, Ferrell, Ferrell, Goldbeter, Gong, Hatakeyama, Hayashi, Hoang, Kholodenko, Kofahl, Kolch, Langlois, Levchenko, Morrison, Muffy Calder, Muller, Murphy, Resat, Rinehart, Sauro, Schoeberl, Somsen, Teis, Vaudry, Vayttaden, Walter Kolch, Wellbrock, Whitehurst, Wiley, Xiong, Yeung   +44 more
core   +1 more source

Role of functionality in two-component signal transduction: A stochastic study [PDF]

Phys Rev E 89 (2014) 032713, 2014
We present a stochastic formalism for signal transduction processes in bacterial two-component system. Using elementary mass action kinetics, the proposed model takes care of signal transduction in terms of phosphotransfer mechanism between the cognate partners of a two-component system, viz, the sensor kinase and the response regulator.
arxiv   +1 more source