Results 81 to 90 of about 736,655 (384)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Forward and Backward Bisimulations for Chemical Reaction Networks [PDF]
, 2015 We present two quantitative behavioral equivalences over species of a chemical reaction network (CRN) with semantics based on ordinary differential equations.
Cardelli, Luca +3 more
core +4 more sources
Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors [PDF]
, 2022 Peitao Zhang +10 more
openalex +1 more source
Not your Mother’s MAPKs: Apicomplexan MAPK function in daughter cell budding
PLOS Pathogens, 2022 Reversible phosphorylation by protein kinases is one of the core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response.
William J. O’Shaughnessy +3 more
openaire +4 more sources
p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1
Journal of Cell Biology, 2018 Inflammation and autophagy are two critical cellular processes. The relationship between these two processes is complex and includes the suppression of inflammation by autophagy.
Yingli He +7 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC [PDF]
, 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data
Barollo, Susi +16 more
core +4 more sources
Journal of Natural Fibers, 2023 Planting economic crops in soil with salt imbalances can improve land use efficiency. Hemp, which can be planted in low-salinity soil, is a crop with a very high economic value. To reveal the salt tolerance mechanism of hemp, the leaves of Longma #3 and #
Ming Zhang +4 more
doaj +1 more source
MAPK Signaling: Sho Business [PDF]
Current Biology, 2004 Sho1 is a membrane protein in yeast that activates the Hog MAPK signaling pathway in response to high osmolarity. An accumulating body of work has focused on Sho1 as a model to better understand the mechanisms that dictate signaling specificity.
Seet, Bruce T., Pawson, Tony
openaire +2 more sources
Molecules, 2017 P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory diseases. Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, as well as neurodegeneration, and ...
Jong Kil Lee, Nam‐Jung Kim
semanticscholar +1 more source