Results 261 to 270 of about 436,308 (305)

ZWINT down-regulated by miR-495-3p inhibited lung metastasis of breast cancer by blocking p38 MAPK signaling pathway activation. [PDF]

Hum Cell
Shao MT, Li WW, Li Y, Chen P, Yu SS, Lu WJ, Chen CM, Dong Y, Zhang YW, Zhang QC.   +9 more
europepmc   +1 more source

Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway. [PDF]

J Orthop Translat
Jin X, Wang X, Xu S, Xu N, Wang Z, Hu C, Liu W, Zhang Z, Liu X, Fan J, Jiang R, Wu R, Lv Z, Shi D.   +13 more
europepmc   +1 more source

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Selaginellin Inhibits Melanogenesis via the MAPK Signaling Pathway

Journal of Natural Products, 2022
Hyperpigmented skin diseases such as melasma, freckles, and melanosis usually mar the appearance of patients. Traditional herbal medicines are highly accepted in inhibiting skin pigmentation, with advantages of high efficiency, low cost, and low side effects.
Ying Zhou, Hong-Liang Zeng, Xin-Yue Wen, Ling Jiang, Chu-Han Fu, Yi-Bo Hu, Xin-Xin Lei, Li Zhang, Xing Yu, Si-Yu Yang, Li-Hua Huang, Hong Xiang, Jin-Hua Huang, Jing Chen, Li Lei, Qing-Hai Zeng   +15 more
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The MAPK signalling pathways and colorectal cancer

The Lancet Oncology, 2005
There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-
Jing Yuan, Fang, Bruce C, Richardson
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MAPK signaling pathways in the regulation of hematopoiesis

Journal of Leukocyte Biology, 2009
Abstract Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an essential role in connecting cell-surface receptors to changes in transcriptional programs.
Geest, C.R., Coffer, P.J
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MAPK signaling pathway-targeted marine compounds in cancer therapy

Journal of Cancer Research and Clinical Oncology, 2021
This paper reviews marine compounds that target the mitogen-activated protein kinase (MAPK) signaling pathway and their main sources, chemical structures, major targeted cancers and possible mechanisms to provide comprehensive and basic information for the development of marine compound-based antitumor drugs in clinical cancer therapy research.This ...
Jiaen Wei, Ruining Liu, Xiyun Hu, Tingen Liang, Zhiran Zhou, Zunnan Huang   +5 more
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The Ras-MAPK Signal Transduction Pathway

Science Signaling, 2010
Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
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High-throughput approaches to dissecting MAPK signaling pathways

Methods, 2006
With the development of genome-wide RNAi libraries, it is now possible to screen for novel components of mitogen-activated protein kinase (MAPK) pathways in cell culture. Although genetic dissection in model organisms and biochemical approaches in mammalian cells have been successful in identifying the core signaling cassettes of these pathways, high ...
Friedman, A., Perrimon, N.
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State machine modeling of MAPK signaling pathways

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014
Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and
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MAPK Signaling Pathways and Their Recursive Modularization

2006 15th International Conference on Computing, 2006
Signal transduction pathways are very complex biochemical networks that include a large number of vital biomolecules and chemical compounds whose activities are dependent on member(s) involved in the network under consideration as well as other networks.
Rajat De, Losiana Nayak
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