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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon +2 more
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MAPK Signaling Pathway in Oral Squamous Cell Carcinoma: Biological Function and Targeted Therapy
Cancers, 2022 Oral squamous cell carcinoma accounts for 95% of human head and neck squamous cell carcinoma cases. It is highly malignant and aggressive, with a poor prognosis and a 5-year survival rate of <50%.
Yuxi Cheng, Juan Chen, Zhangui Tang
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Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer
International Journal of Molecular Sciences, 2022 The advancement in high-throughput sequencing analysis and the evaluation of chromatin state maps have revealed that eukaryotic cells produce many non-coding transcripts/RNAs.
Jianguo Feng +2 more
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Life Sciences, 2021 Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved signaling pathway, is reported to be involved in various biological events, including metabolic reprogramming, cell proliferation, survival, and differentiation. Mutations
Elmira Roshani Asl +2 more
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MAPK signaling pathways in the regulation of hematopoiesis
Journal of Leukocyte Biology, 2009Abstract Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an essential role in connecting cell-surface receptors to changes in transcriptional programs.
Christian R, Geest, Paul J, Coffer
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The MAPK signalling pathways and colorectal cancer
The Lancet Oncology, 2005There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-
Jing Yuan, Fang, Bruce C, Richardson
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Selaginellin Inhibits Melanogenesis via the MAPK Signaling Pathway
Journal of Natural Products, 2022Hyperpigmented skin diseases such as melasma, freckles, and melanosis usually mar the appearance of patients. Traditional herbal medicines are highly accepted in inhibiting skin pigmentation, with advantages of high efficiency, low cost, and low side effects.
Ying Zhou +15 more
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Allosteric activation of RAF in the MAPK signaling pathway
Current Opinion in Structural Biology, 2018Protein kinases are evolutionarily crafted into two functional states. In response to stimuli, kinase, which is usually populated in an inactive state, becomes active. Here, we outline a unified scheme to explain how kinases are activated physiologically and pathologically, focusing on RAF allosteric activation.
Chung-Jung, Tsai, Ruth, Nussinov
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The Ras-MAPK Signal Transduction Pathway
Science Signaling, 2010Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
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MAPK Signaling Pathways and Their Recursive Modularization
2006 15th International Conference on Computing, 2006Signal transduction pathways are very complex biochemical networks that include a large number of vital biomolecules and chemical compounds whose activities are dependent on member(s) involved in the network under consideration as well as other networks.
Rajat De, Losiana Nayak
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