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A timeliness metrics analysis study was carried out in Tanzania. A total of 98 disease outbreaks were recorded. The time taken to detect, verify and respond to zoonotic diseases was shorter than the time for non‐zoonotic diseases. More investment should be done for the timely management of disease in Tanzania.
Esron Karimuribo+5 more
wiley +1 more source
Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline+9 more
core +1 more source
Postexposure Treatment of Marburg Virus Infection
Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.
Joan B. Geisbert+6 more
openaire +4 more sources
From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley +1 more source
Anticipating the species jump: surveillance for emerging viral threats. [PDF]
Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by what methods?
Bush, RM+5 more
core +1 more source
Experimental Success in Marburg Virus Vaccination
The Marburg virus (MRV), classified within the Filoviridae family, was initially identified in 1967, precipitating Marburg virus disease (MARV), a severe and often fatal hemorrhagic fever.
Martyna Dydyk, Aleksandra Nowak
doaj +1 more source
Viral antibody dynamics in a chiropteran host [PDF]
1. Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated.<p></p> 2.
Baker, K.S.+10 more
core +1 more source
Current PAT Landscape in the Downstream Processing of Biopharmaceuticals
ABSTRACT Protein‐based therapeutics have revolutionized modern medicine, addressing complex diseases with unprecedented specificity and efficacy. The rising demand for biologics has driven the evolution of biomanufacturing practices to ensure consistent quality and operational efficiency.
Pavithra Sathiyapriyan+6 more
wiley +1 more source
Characterization of the Hemagglutinin Cleaving Transmembrane Serine Proteases Matriptase and TMPRSS2 [PDF]
Influenza is one of the commonest infectious diseases affecting millions of people every year including 290,000 – 650,000 heavy casualties. Influenza viruses undergo constant genetic changes and every 10 – 50 years new influenza virus strains emerge that
Keils, Aline
core +1 more source
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson+78 more
core +2 more sources