Results 91 to 100 of about 4,442 (181)

Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]

, 2015
Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron, Bertherat, Blackley, Burke, Christie, De Roo, Faye, Formenty, Hall, Julii Brainard, Katherine Pond, Kelly Edmunds, Kunii, Lee Hooper, Mackay, McElroy, Moreau, Mupere, Nyenswah, Nyenswah, Nyenswah, Olabode, Paul R Hunter, Schibler, Victory, Vladyko, World Health Organization   +26 more
core   +1 more source

MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fevers [PDF]

, 2006
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in clinical management.
Briese, Thomas, Drosten, Christian, Feldmann, Heinz, Geisbert, Thomas W., Grolla, Allen, Jabado, Omar J., Jahrling, Peter B., Ju, Jingyue, Kapoor, Vishal, Lipkin, W. Ian, Liu, Zhiqiang, Nichol, Stuart T., Palacios, Gustavo F., Paweska, Janusz, Renwick, Neil, Swanepoel, Robert, Towner, Jonathan, Venter, Marietjie, Zhai, Junhui   +18 more
core   +2 more sources

Survey and Visual Detection of Zaire ebolavirus in Clinical Samples Targeting the Nucleoprotein Gene in Sierra Leone [PDF]

, 2015
Ebola virus (EBOV) can lead to severe hemorrhagic fever with a high risk of death in humans and other primates. To guide treatment and prevent spread of the viral infection, a rapid and sensitive detection method is required for clinical samples.
Boxing Li, Chao Liu, Derong Dong, Erna Li, Huan Li, Jing Yuan, Lifei Cui, Puyuan Li, Wei Liu, Weishi Lin, Xiangna Zhao, Xiao Wei, Xuan Hu, Xuesong Wang, Yanyan Ma   +14 more
core   +2 more sources

Marburg Virus Disease in Sub-Saharan Africa: A Review of Currently Available Comprehensive Genomic Data up to 2024

Zoonotic Diseases
Marburg virus (MARV) is one of the deadliest human zoonotic pathogens, historically traced back to Uganda, in East African-cave-dwelling Egyptian fruit bats (Rousettus aegyptiacus), the probable cradle of MARV.
Edson Kinimi
doaj   +1 more source

Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels

Scientific Reports, 2017
Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature.
Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Stuart T. Nichol, Jonathan S. Towner   +5 more
doaj   +1 more source

A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease

mSphere, 2018
Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA’s Animal Efficacy Rule, which requires well-characterized ...
Kendra J. Alfson, Laura E. Avena, Jenny Delgado, Michael W. Beadles, Jean L. Patterson, Ricardo Carrion, Anthony Griffiths   +6 more
doaj   +1 more source

Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer [PDF]

, 2017
Filovirus infections cause hemorrhagic fever in humans and non-human primates that often results in high fatality rates. The Marburg virus is a lipid-enveloped virus from the Filoviridae family and is closely related to the Ebola virus.
Bhattarai, Nisha, Chapagain, Prem P., GC, Jeevan B., Gerstman, Bernard S., Stahelin, Robert V.   +4 more
core   +1 more source

Coordinated inflammatory responses dictate Marburg virus control by reservoir bats

Nature Communications
Bats are increasingly recognized as reservoirs of emerging zoonotic pathogens. Egyptian rousette bats (ERBs) are the known reservoir of Marburg virus (MARV), a filovirus that causes deadly Marburg virus disease (MVD) in humans.
Jonathan C. Guito, Shannon G. M. Kirejczyk, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, James Graziano, Jessica R. Spengler, Jessica R. Harmon, David M. Wozniak, Joseph B. Prescott, Jonathan S. Towner   +10 more
doaj   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

Rapid Development of Modified Vaccinia Virus Ankara (MVA)-Based Vaccine Candidates Against Marburg Virus Suitable for Clinical Use in Humans

Vaccines
Background/Objectives: Marburg virus (MARV) is the etiological agent of Marburg Virus Disease (MVD), a rare but severe hemorrhagic fever disease with high case fatality rates in humans.
Alina Tscherne, Georgia Kalodimou, Alexandra Kupke, Cornelius Rohde, Astrid Freudenstein, Sylvia Jany, Satendra Kumar, Gerd Sutter, Verena Krähling, Stephan Becker, Asisa Volz   +10 more
doaj   +1 more source