Results 11 to 20 of about 3,469 (122)
Molecular insights into nucleocapsid assembly and transport in Marburg and Ebola viruses [PDF]
mBioLive-cell imaging enables visualization of the spatiotemporal dynamics of signals in cells. Intracytoplasmic movement of nucleocapsids is crucial during the life cycle of enveloped viruses; however, the molecular mechanisms governing their assembly and ...
Yuki Takamatsu +7 more
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Marburg Virus VP30 Is Required for Transcription Initiation at the Glycoprotein Gene
mBio, 2022 Marburg virus (MARV) is an enveloped, negative-sense RNA virus from the filovirus family that causes outbreaks of severe, frequently fatal illness in humans. Of the seven MARV proteins, the VP30 protein stands out because it is essential for viral growth
Megan R. Edwards +4 more
doaj +1 more source
Preparation of Class Y Immunoglobulins that Neutralize the Marburg Virus
Проблемы особо опасных инфекций, 2021 The aim was to study the possibility of inducing Marburg-neutralizing chicken antibodies (MARV) using various immunogens.Materials and methods. Recombinant vaccinia virus expressing the surface glycoprotein (GP) transgene MARV of Musoke strain and ...
O. A. Polezhaeva +7 more
doaj +1 more source
Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. [PDF]
PLoS Pathogens, 2015 The filoviruses, which include the marburg- and ebolaviruses, have caused multiple outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein (GP) have been shown to provide life-saving therapy in nonhuman primates, but ...
Marnie L Fusco +18 more
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Marburg Virus Persistence on Fruit as a Plausible Route of Bat to Primate Filovirus Transmission
Viruses, 2021 Marburg virus (MARV), the causative agent of Marburg virus disease, emerges sporadically in sub-Saharan Africa and is often fatal in humas. The natural reservoir for this zoonotic virus is the frugivorous Egyptian rousette bat (Rousettus aegyptiacus ...
Brian R. Amman +3 more
doaj +1 more source
Single-Shot ChAd3-MARV Vaccine in Modified Formulation Buffer Shows 100% Protection of NHPs
Vaccines, 2022 Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24–88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no candidate ...
Courtney L. Finch +18 more
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An introduction to the Marburg virus vaccine consortium, MARVAC
PLoS Pathogens, 2022 The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine “MARVAC” consortium representing leaders in the field of vaccine research and development aiming to facilitate a rapid response to this infectious ...
Robert W. Cross +44 more
doaj +3 more sources
Obtaining Recombinant Antigens for the Development of Serological Diagnosis of Marburg Fever
Проблемы особо опасных инфекций, 2021 Aim. Production of recombinant viral antigens of the main immunodominant proteins: glycoprotein (GPΔMLD), nucleoprotein (NP) and matrix protein (VP40) of the Marburg virus, as well as the study of their antigenic and immunogenic properties.Materials and ...
N. V. Volkova +6 more
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Development of an Immunochromatography Assay to Detect Marburg Virus and Ravn Virus
Viruses, 2023 The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV),
Katendi Changula +13 more
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Проблемы особо опасных инфекций, 2022 The aim of the study was to create a highly immunogenic vaccine construct based on a recombinant variant of a replication-defective MVA strain of vaccinia virus, expressing virus-like particles that mimic natural infection with Marburg virus.
A. V. Semenova +14 more
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