Results 51 to 60 of about 1,166,657 (155)

Marburg virus pathogenesis – differences and similarities in humans and animal models

Virology Journal, 2019
Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients ...
Kyle Shifflett, Andrea Marzi
doaj   +1 more source

DESAIN VAKSIN MULTI-EPITOP TERHADAP VIRUS MARBURG (MARV) BERBASIS PROTEIN VP35 MENGGUNAKAN PENDEKATAN IMMUNOINFORMATIKA: IN-SILICO

Pharmacoscript
Virus Marburg (MARV) merupakan salah satu virus zoonosis dari keluarga Filoviridae dengan tingkat kematian hingga 88%. Pertumbuhan populasi global yang pesat meningkatkan risiko paparan penyakit akibat perubahan iklim dan ekologi. Untuk pencegahan, vaksin menjadi upaya terbaik.
Asopari Ilham Nurfadilah, Pratita Anindita Tri Kusuma, Mardianingrum Richa, Ruswanto Ruswanto   +3 more
openaire   +1 more source

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

Nature Communications, 2019
Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV).
Jennifer M. Brannan, Shihua He, Katie A. Howell, Laura I. Prugar, Wenjun Zhu, Hong Vu, Sergey Shulenin, Shweta Kailasan, Henna Raina, Gary Wong, Md Niaz Rahim, Logan Banadyga, Kevin Tierney, Xuelian Zhao, Yuxing Li, Frederick W. Holtsberg, John M. Dye, Xiangguo Qiu, M. Javad Aman   +18 more
doaj   +1 more source

Putative Novel Viruses in the Families Lispiviridae and Rhabdoviridae Detected in Culex and Anopheles Mosquitoes Collected at the São Paulo Zoo

Advances in Virology, Volume 2026, Issue 1, 2026.
Several viruses belonging to the order Mononegavirales are recognized as highly pathogenic in humans and are often associated with lethal disease outcomes. Prominent examples include human respiratory syncytial virus (HRSV), Ebola virus (EBOV), rabies virus (RABV), and Marburg virus (MARV).
Lilian de Oliveira Guimarães, Roseane da Silva Couto, Geovani de Oliveira Ribeiro, Juliana Telles-de-Deus, Endrya do Socorro Foro Ramos, Vanessa Christe Helfstein, Vanessa dos Santos Morais, Jesus Maia dos Santos, Ramendra Pati Pandey, Vera Lucia Fonseca de Camargo-Neves, Antonio Charlys da Costa, Karin Kirchgatter, Élcio Leal, Claudia Veronica Filomatori   +13 more
wiley   +1 more source

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry [PDF]

, 2015
Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs.
Temperton, Nigel J., Molesti, E, Barclay, W., Barclay, W, Wendy Barclay (686216), Eleonora Molesti, Nigel Temperton (5830610), Temperton, N, Barclay, Wendy, Edward Wright, Long, J., Molesti, E., Edward Wright (4468198), Molesti, Eleonora, Temperton, N., Long, Jason, Wright, E, Jason Long (40805), Wendy Barclay, Eleonora Molesti (686215), Wright, Edward, Wright, E., Nigel Temperton, Long, J, Jason Long   +24 more
core   +1 more source

Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Rousettus aegyptiacus)

Journal of Virology
Viral coinfections and their impact on long-term immunity represent an understudied area in disease ecology and infectious disease research. Coinfections can influence the host’s susceptibility to future infections, alter host and pathogen population ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +1 more source

Vaccine Platform Comparison: Protective Efficacy against Lethal Marburg Virus Challenge in the Hamster Model [PDF]

Marburg virus (MARV), a filovirus, was first identified in 1967 in Marburg, Germany, and Belgrade, former Yugoslavia. Since then, MARV has caused sporadic outbreaks of human disease with high case fatality rates in parts of Africa, with the largest ...
Andrea Marzi, Jesse H. Erasmus, Corey W. Henderson, Joan Fusco, Hanna Anhalt, Teresa Lambe, Kyle L. O’Donnell   +6 more
core   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura   +4 more
wiley   +1 more source