Results 61 to 70 of about 1,166,657 (155)

Reciprocal endpoint dilution titers of anti-MARV GP IgG and IgM in Vesiculovax-vaccinated cynomolgus macaques.

, 2022
MARV GP-specific (A) IgG and (B) IgM titers in vaccinated cohorts immunized with rVSV-N4CT1-MARV-GP at -7 DPI (blue; n = 5), -5 DPI (brown; n = 5), or -3DPI (red; n = 5), or a vector control (black; n = 3). The mean titer ± SEM is shown for each group at
Daniel J. Deer (9239745), Joan B. Geisbert (9239739), Demetrius Matassov (12667337), Viktoriya Borisevich (546564), Robert W. Cross (9239733), Theresa E. Latham (5774444), Cheryl Gerardi (12667328), Karla A. Fenton (9188846), Michael A. Egan (12667331), Thomas W. Geisbert (9239748), John H. Eldridge (12667334), Krystle N. Agans (9239742), Courtney Woolsey (9254949)   +12 more
core   +1 more source

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

Data_Sheet_1_Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation.pdf

, 2019
Marburg virus (MARV) is the causative agent of hemorrhagic fever outbreaks with high case fatality rates. Closely related to Ebola virus, MARV is a filamentous virus with a negative-sense, single-stranded RNA genome.
Andrea Marzi (146489), Allen Jankeel (6249761), Flora Engelmann (257295), Andrea R. Menicucci (6249755), Julie Callison (5085575), Heinz Feldmann (18301), Friederike Feldmann (151957), Ilhem Messaoudi (72928), Eva J. Horne (6249758)   +8 more
core   +1 more source

Rapid protection of nonhuman primates against Marburg virus disease using a single low-dose VSV-based vaccineResearch in context

EBioMedicine, 2023
Summary: Background: Marburg virus (MARV) is the causative agent of Marburg virus disease (MVD) which has a case fatality rate up to ∼90% in humans. Recently, there were cases reported in Guinea and Ghana highlighting this virus as a high-consequence ...
Kyle L. O'Donnell, Friederike Feldmann, Benjamin Kaza, Chad S. Clancy, Patrick W. Hanley, Paige Fletcher, Andrea Marzi   +6 more
doaj   +1 more source

Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology

Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker, Amanda Vicente‐Santos, Ashley B. Reers, B. R. Ansil, Mika O'Shea, Caroline A. Cummings, Alicia J. Roistacher, Rita M. Quintela‐Tizon, Manuela M. T. Pereira, Juniper Rosen, Arinjay Banerjee, Hannah K. Frank   +11 more
wiley   +1 more source

Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using Drosophila S2 Cells

Engineering in Life Sciences, Volume 25, Issue 5, May 2025.
ABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Sven Göbel, Ludwig Mayerlen, Isabelle Yazel Eiser, Lisa Fichtmueller, David Clements, Udo Reichl, Yvonne Genzel, AxelT. Lehrer   +7 more
wiley   +1 more source

Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Rousettus aegypticus)

Journal of Virology
Marburg virus (MARV) and Ravn virus (RAVV), the only two known members of the species Orthomarburgvirus marburgense (family Filoviridae), are causative agents of Marburg virus disease, a severe viral disease that typically emerges in sub-Saharan Africa ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +1 more source

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Cell Reports, 2020
Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species.
Yoshihiro Takadate, Tatsunari Kondoh, Manabu Igarashi, Junki Maruyama, Rashid Manzoor, Hirohito Ogawa, Masahiro Kajihara, Wakako Furuyama, Masahiro Sato, Hiroko Miyamoto, Reiko Yoshida, Terence E. Hill, Alexander N. Freiberg, Heinz Feldmann, Andrea Marzi, Ayato Takada   +15 more
doaj   +1 more source

Rescue and characterization of the first West African Marburg virus 2021 from Guinea

Marburg virus (MARV) is a causative agent of a severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks of MARV in Equatorial Guinea and Tanzania underline the relevance of MARV as a public health emergency pathogen.
Schneider, Jana, Benz, Marcel, Lier, Clemens, Kämper, Lennart, Schauflinger, Martin, Rohde, Cornelius, Gerresheim, Gesche K., Eickmann, Markus, von Creytz, Isabel, Biedenkopf, Nadine   +9 more
core   +1 more source

Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design

Nature Communications
Limited knowledge exists on the quality of polyclonal antibody responses generated following Marburg virus (MARV) infection and its evolution in survivors.
Surender Khurana, Gabrielle Grubbs, Supriya Ravichandran, Emily Cluff, JungHyun Kim, Ana I. Kuehne, Samantha Zak, John M. Dye, Julius J. Lutwama, Andrew S. Herbert   +9 more
doaj   +1 more source