Results 81 to 90 of about 4,442 (181)

Marburg Virus Reverse Genetics Systems

Viruses, 2016
The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses.
Kristina Maria Schmidt, Elke Mühlberger
doaj   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge.

PLoS Neglected Tropical Diseases, 2022
BackgroundMarburg virus (MARV), an Ebola-like virus, remains an eminent threat to public health as demonstrated by its high associated mortality rate (23-90%) and recent emergence in West Africa for the first time.
Courtney Woolsey, Robert W Cross, Krystle N Agans, Viktoriya Borisevich, Daniel J Deer, Joan B Geisbert, Cheryl Gerardi, Theresa E Latham, Karla A Fenton, Michael A Egan, John H Eldridge, Thomas W Geisbert, Demetrius Matassov   +12 more
doaj   +1 more source

VP24-Karyopherin alpha binding affinities differ between Ebolavirus species, nfluencing interferon inhibition and VP24 stability [PDF]

, 2017
Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties.
Alinger, Joshua B, Amarasinghe, Gaya K, Basler, Christopher F, Diederichs, Audrey, Edwards, Megan R, Leung, Daisy W, Schwarz, Toni M   +6 more
core   +2 more sources

Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)

Viruses, 2016
Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be ...
John M. Dye, Kelly L. Warfield, Jay B. Wells, Robert C. Unfer, Sergey Shulenin, Hong Vu, Donald K. Nichols, M. Javad Aman, Sina Bavari   +8 more
doaj   +1 more source

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]

, 2012
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Chandran, Kartik, Dye, John M., Herbert, Andrew S., Krishnan, Anuja, Miller, Emily Happy, Ndungo, Esther, Ng, Melinda, Whelan, Sean P.J.   +7 more
core   +2 more sources

The current landscape of nucleic acid tests for filovirus detection. [PDF]

, 2018
Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed.
Agnandji, Agnandji, Al-Soud, Al-Soud, Andrew D. Sails, Benzine, Bergqvist, Biek, Boyd, Cai, Carinelli, Chua, Chughtai, Cnops, David J. Clark, De Santis, Deen, Drosten, Duy, Dye, Ewer, FDA, Gay-Andrieu, Geisbert, Gibb, Greninger, Haddock, Hayman, Henao-Restrepo, Henry M. Staines, Huttner, Jayme, John Tyson, Kibuuka, Koehler, Kurosaki, Kurosaki, Kurosaki, Laing, Ledgerwood, Leroy, Leroy, Leski, Loftis, Lu, Mate, Milligan, Ogawa, Ogawa, Oloniniyi, Park, Pattyn, Pettitt, Pinsky, Pourrut, Pyankov, Quick, Raftery, Regules, Rieger, Rodriguez, Rossi, Sanchez, Sanjeev Krishna, Schrader, Semper, Shah, Southern, Spengler, Swanepoel, Tapia, Towner, Towner, Trombley, Varkey, Waxman, Weidmann, Weingartl, Weller, WHO, WHO, Wong, Woolhouse, Xu, Zheng, Zhu   +85 more
core   +1 more source

Lyophilisation of lentiviral pseudotypes for the development and distribution of virus neutralisation assay kits for rabies, Marburg and influenza viruses [PDF]

, 2014
Purpose: Some conventional serological assays can accurately quantify neutralising antibody responses raised against epitopes on virus glycoproteins, enabling mass vaccine evaluation and serosurveillance studies to take place. However, these assays often
Mather, Stuart, Scott, Simon D., Temperton, Nigel J., Wright, Edward   +3 more
core  

A Loop Region in the N-Terminal Domain of Ebola Virus VP40 Is Important in Viral Assembly, Budding, and Egress [PDF]

, 2014
Ebola virus (EBOV) causes viral hemorrhagic fever in humans and can have clinical fatality rates of ~60%. The EBOV genome consists of negative sense RNA that encodes seven proteins including viral protein 40 (VP40).
Adu-Gyamfi, Emmanuel, Digman, Michelle A., Gratton, Enrico, Jee, Clara S., Soni, Smita P., Stahelin, Robert V.   +5 more
core   +3 more sources