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Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]

open access: yesMolecular Aspects of Medicine, 2008
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
Antonino Di Caro, , Alessio Bocedi
exaly   +8 more sources

Budding of Marburgvirus is associated with filopodia [PDF]

open access: yesCellular Microbiology, 2007
Viruses exploit the cytoskeleton of host cells to transport their components and spread to neighbouring cells. Here we show that the actin cytoskeleton is involved in the release of Marburgvirus (MARV) particles. We found that peripherally located nucleocapsids and envelope precursors of MARV are located either at the tip or at the side of filopodial ...
Richard Cheney, Stephan Becker
exaly   +3 more sources
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Reemergence of Marburgvirus disease: Update on current control and prevention measures and review of the literature

Reviews in Medical Virology, 2023
AbstractIn 1967, the very first case of the Marburgvirus disease (MVD) was detected in Germany and Serbia sequentially. Since then, MVD has been considered one of the most serious and deadly infectious diseases in the world with a case‐fatality rate between 23% and 90% and a substantial number of recorded deaths.
Sara A Khader   +2 more
exaly   +3 more sources

Marburgvirus Nucleoprotein-Capture Enzyme-Linked Immunosorbent Assay Using Monoclonal Antibodies to Recombinant Nucleoprotein: Detection of Authentic Marburgvirus

open access: yesJapanese Journal of Infectious Diseases, 2006
There have recently been large outbreaks of Marburg hemorrhagic fever (MHF) caused by Marburgvirus (MARV) in the Democratic Republic of Congo and Angola. The development of reliable diagnostic systems for MHF is urgently needed. An antigen-capture enzyme-linked immunosorbent assay (Ag-capture ELISA) using either of the two monoclonal antibodies (2A7 ...
Masayuki Saijo   +2 more
exaly   +3 more sources

Immunoinformatic screening of Marburgvirus epitopes and computational investigations of epitope-allele complexes

International Immunopharmacology, 2022
Marburgvirus (MARV), a member of the Filovirus family, causes severe hemorrhagic fever in humans. Currently, there are no approved vaccines or post exposure treatment methods available against MARV. With the aim of identifying vaccine candidates against MARV, we employ different sequence-based computational methods to predict the MHC-I and MHC-II T ...
Prabin Baral   +2 more
exaly   +3 more sources

Pseudotyped Viruses for Marburgvirus and Ebolavirus

2023
Marburg virus (MARV) and Ebola virus (EBOV) of the Filoviridae family are the most lethal viruses in terms of mortality rate. However, the development of antiviral treatment is hampered by the requirement for biosafety level-4 (BSL-4) containment. The establishment of BSL-2 pseudotyped viruses can provide important tools for the study of filoviruses ...
Li, Zhang, Shou, Liu, Youchun, Wang
openaire   +2 more sources

Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola [PDF]

open access: yesJournal of Virology, 2006
ABSTRACT In March 2005, the Centers for Disease Control and Prevention (CDC) investigated a large hemorrhagic fever (HF) outbreak in Uige Province in northern Angola, West Africa. In total, 15 initial specimens were sent to CDC, Atlanta, Ga., for testing for viruses associated with viral HFs known to be present in West Africa ...
Amy Hartman   +2 more
exaly   +3 more sources

Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription [PDF]

open access: yesJournal of Virology, 2005
ABSTRACT The nucleocapsid protein VP35 of Marburgvirus, a filovirus, acts as the cofactor of the viral polymerase and plays an essential role in transcription and replication of the viral RNA. VP35 forms complexes with the genome encapsidating protein NP and with the RNA-dependent RNA polymerase L.
Stephan Becker, Nonia Pariente
exaly   +3 more sources

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