Results 131 to 140 of about 1,487 (150)
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Virology, 2017 Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling.
Jonathan S Towner +2 more
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Conserved Receptor-binding Domains of Lake Victoria Marburgvirus and Zaire Ebolavirus Bind a Common Receptor [PDF]
Journal of Biological Chemistry, 2006 The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1.
Sina Bavari +2 more
exaly +3 more sources
2023
Abstract We utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus +7 more
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Abstract We utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus +7 more
openaire +1 more source
Phosphorylation of Marburgvirus NP and its influence on the viral life cycle
2016Das Marburgvirus (MARV) bildet zusammen mit Ebolavirus (EBOV) und Lloviuvirus (LLOV) die Familie der Filoviridae und besitzt ein einzelsträngiges RNA-Genom negativer Orientierung. Filoviren werden als BSL-4-Pathogene klassifiziert, da sie schwere hämorrhagische Fieber bei Menschen und Affen verursachen. Das Nukleoprotein
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Analysis of Ebolavirus and Marburgvirus using data mining
2015J Jeong, B Kim, T Yoon
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