Results 171 to 180 of about 2,647 (192)

Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola [PDF]

Journal of Virology, 2006
ABSTRACT In March 2005, the Centers for Disease Control and Prevention (CDC) investigated a large hemorrhagic fever (HF) outbreak in Uige Province in northern Angola, West Africa. In total, 15 initial specimens were sent to CDC, Atlanta, Ga., for testing for viruses associated with viral HFs known to be present in West Africa ...
Jonathan S Towner, Ute Ströher, Pierre E Rollin   +2 more
exaly   +3 more sources

Marburgvirus Nucleoprotein-Capture Enzyme-Linked Immunosorbent Assay Using Monoclonal Antibodies to Recombinant Nucleoprotein: Detection of Authentic Marburgvirus

Japanese Journal of Infectious Diseases, 2006
There have recently been large outbreaks of Marburg hemorrhagic fever (MHF) caused by Marburgvirus (MARV) in the Democratic Republic of Congo and Angola. The development of reliable diagnostic systems for MHF is urgently needed. An antigen-capture enzyme-linked immunosorbent assay (Ag-capture ELISA) using either of the two monoclonal antibodies (2A7 ...
Masayuki, Saijo, Marie-Claude, Georges-Courbot, Shuetsu, Fukushi, Tetsuya, Mizutani, Marianneau, Philippe, Alain-Jean, Georges, Ichiro, Kurane, Shigeru, Morikawa   +7 more
exaly   +3 more sources

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Reemergence of Marburgvirus disease: Update on current control and prevention measures and review of the literature

Reviews in Medical Virology, 2023
AbstractIn 1967, the very first case of the Marburgvirus disease (MVD) was detected in Germany and Serbia sequentially. Since then, MVD has been considered one of the most serious and deadly infectious diseases in the world with a case‐fatality rate between 23% and 90% and a substantial number of recorded deaths.
Randa Elsheikh, Abdelrahman M Makram, Hager Selim   +2 more
exaly   +3 more sources

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding [PDF]

Cell Host and Microbe, 2018
Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%-90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in non-human primates when delivered several days after inoculation of a lethal marburgvirus ...
Liam B King, Andrew Flyak, Kai Huang
exaly   +4 more sources

Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription [PDF]

Journal of Virology, 2005
ABSTRACT The nucleocapsid protein VP35 of Marburgvirus, a filovirus, acts as the cofactor of the viral polymerase and plays an essential role in transcription and replication of the viral RNA. VP35 forms complexes with the genome encapsidating protein NP and with the RNA-dependent RNA polymerase L.
Stephan Becker
exaly   +3 more sources

Conserved Receptor-binding Domains of Lake Victoria Marburgvirus and Zaire Ebolavirus Bind a Common Receptor [PDF]

Journal of Biological Chemistry, 2006
The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1.
Jens H Kuhn, Wenhui Li, Jonathan S Towner   +2 more
exaly   +3 more sources

Marburgvirus

2009
exaly   +2 more sources

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system

Virology, 2017
Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling.
Catherine E Arnold, César G Albariño, Jonathan S Towner   +2 more
exaly   +3 more sources

Cross-reactive macaque antibodies targeting marburgvirus glycoprotein induced by multivalent immunization

2023
AbstractWe utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus, Ruixue Wang, Thomas E. Cleveland, Matthew C. Metcalf, Aaron C. Lemmer, Kenneth Class, Thomas R. Fuerst, Gilad Ofek   +7 more
openaire   +1 more source

Phosphorylation of Marburgvirus NP and its influence on the viral life cycle

2016
Das Marburgvirus (MARV) bildet zusammen mit Ebolavirus (EBOV) und Lloviuvirus (LLOV) die Familie der Filoviridae und besitzt ein einzelsträngiges RNA-Genom negativer Orientierung. Filoviren werden als BSL-4-Pathogene klassifiziert, da sie schwere hämorrhagische Fieber bei Menschen und Affen verursachen. Das Nukleoprotein
openaire   +1 more source