Results 1 to 10 of about 542,757 (179)

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence

Viruses, 2022
Marek’s disease virus (MDV) causes malignant lymphoma in chickens (Marek’s disease, MD). Although MD is currently controlled by vaccination, MDV strains have continuously increased in virulence over the recent decades.
Jumpei Sato, Shiro Murata, Zhiyuan Yang, Benedikt B. Kaufer, Sotaro Fujisawa, Hikari Seo, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Nikolaus Osterrieder, Mark S. Parcells, Kazuhiko Ohashi   +11 more
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The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

PLoS Biology, 2021
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman   +9 more
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A Special Issue on Marek’s Disease Virus—The Editors’ View [PDF]

Microorganisms, 2023
Marek’s disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [...]
Benedikt B. Kaufer, Mark S. Parcells, Luca D. Bertzbach   +2 more
doaj   +2 more sources

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America [PDF]

Evolutionary Applications, 2017
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus
Groenke, Nicole, He, Shulin, Jenckel, Maria, Kunec, Dusan, McMahon, Dino P., Osterrieder, Nikolaus, Spatz, Stephen J., Szpara, Moriah L., Trimpert, Jakob   +8 more
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A Novel Effective and Safe Vaccine for Prevention of Marek’s Disease Caused by Infection with a Very Virulent Plus (vv+) Marek’s Disease Virus

Vaccines, 2021
Marek’s disease virus (MDV) is a highly contagious alphaherpesvirus that causes rapid onset lymphoma in chickens. Marek’s disease (MD) is effectively controlled using vaccination; however, MDV continues to break through vaccinal immunity, due to the ...
Yifei Liao, Sanjay M. Reddy, Owais A. Khan, Aijun Sun, Blanca Lupiani   +4 more
doaj   +2 more sources

Surveillance and Molecular Characterization of Marek’s Disease Virus (MDV) Strains Circulating in Tanzania [PDF]

Viruses
Marek’s disease (MD) is a highly contagious and oncogenic viral disease of poultry, causing significant economic losses due to mortality and reduced performance. The rapid evolution of Marek’s disease virus (MDV) has been reported in poultry farms, often
Augustino Alfred Chengula, Herbertha Mpete, Ramadhani Juma Makasali   +2 more
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A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene [PDF]

mSphere, 2019
Vaccines play a crucial role in the protection of animals and humans from deadly pathogens. The first vaccine that also protected against cancer was developed against the highly oncogenic herpesvirus Marek’s disease virus (MDV).
Andelé M. Conradie, Luca D. Bertzbach, Nirajan Bhandari, Mark Parcells, Benedikt B. Kaufer   +4 more
doaj   +3 more sources

Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations [PDF]

Virology Journal
Background Marek’s disease virus (MDV) causes Marek’s disease (MD) in chickens, which is characterized by malignant lymphomas and neurological disorders.
Jumpei Sato, Aoi Kurokawa, Yoshinosuke Motai, Shunsuke Yamagami, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Benedikt B. Kaufer, Nikolaus Osterrieder, Mark S. Parcells, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +14 more
doaj   +2 more sources

Marek’s Disease Virus Infection of Natural Killer Cells

Microorganisms, 2019
Natural killer (NK) cells are key players in the innate immune response. They kill virus-infected cells and are crucial for the induction of adaptive immune responses. Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that causes deadly
Luca D. Bertzbach, Daphne A. van Haarlem, Sonja Härtle, Benedikt B. Kaufer, Christine A. Jansen   +4 more
doaj   +2 more sources

Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS [PDF]

Frontiers in Microbiology, 2023
Marek’s disease (MD) caused by Marek’s disease virus (MDV), poses a serious threat to the poultry industry by inducing neurological disease and malignant lymphoma in infected chickens.
Qingsen Wang, Qingsen Wang, Qingsen Wang, Bin Shi, Bin Shi, Bin Shi, Guifu Yang, Guifu Yang, Guifu Yang, Xueying Zhu, Xueying Zhu, Xueying Zhu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +23 more
doaj   +2 more sources