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A Special Issue on Marek’s Disease Virus—The Editors’ View [PDF]

Microorganisms, 2023
Marek’s disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [...]
Benedikt B. Kaufer, Mark S. Parcells, Luca D. Bertzbach   +2 more
doaj   +2 more sources

Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations [PDF]

Virology Journal
Background Marek’s disease virus (MDV) causes Marek’s disease (MD) in chickens, which is characterized by malignant lymphomas and neurological disorders.
Jumpei Sato, Aoi Kurokawa, Yoshinosuke Motai, Shunsuke Yamagami, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Benedikt B. Kaufer, Nikolaus Osterrieder, Mark S. Parcells, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +14 more
doaj   +2 more sources

A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene [PDF]

mSphere, 2019
Vaccines play a crucial role in the protection of animals and humans from deadly pathogens. The first vaccine that also protected against cancer was developed against the highly oncogenic herpesvirus Marek’s disease virus (MDV).
Andelé M. Conradie, Luca D. Bertzbach, Nirajan Bhandari, Mark Parcells, Benedikt B. Kaufer   +4 more
doaj   +3 more sources

Surveillance and Molecular Characterization of Marek’s Disease Virus (MDV) Strains Circulating in Tanzania [PDF]

Viruses
Marek’s disease (MD) is a highly contagious and oncogenic viral disease of poultry, causing significant economic losses due to mortality and reduced performance. The rapid evolution of Marek’s disease virus (MDV) has been reported in poultry farms, often
Augustino Alfred Chengula, Herbertha Mpete, Ramadhani Juma Makasali   +2 more
doaj   +2 more sources

Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS [PDF]

Frontiers in Microbiology, 2023
Marek’s disease (MD) caused by Marek’s disease virus (MDV), poses a serious threat to the poultry industry by inducing neurological disease and malignant lymphoma in infected chickens.
Qingsen Wang, Qingsen Wang, Qingsen Wang, Bin Shi, Bin Shi, Bin Shi, Guifu Yang, Guifu Yang, Guifu Yang, Xueying Zhu, Xueying Zhu, Xueying Zhu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +23 more
doaj   +2 more sources

The Role of Artificial Intelligence in Herpesvirus Detection, Transmission, and Predictive Modeling: With a Special Focus on Marek’s Disease Virus [PDF]

Pathogens
Herpesvirus infections, including herpes simplex virus (HSV), Epstein–Barr virus (EBV), and cytomegalovirus (CMV), present significant challenges in diagnosis, treatment, and transmission control.
Haji Akbar
doaj   +2 more sources

Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus [PDF]

Viruses
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence.
Jumpei Sato, Yoshinosuke Motai, Shunsuke Yamagami, Aoi Kurokawa, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +11 more
doaj   +2 more sources

Overexpression of Interleukin-17 Modulates Responses to Marek’s Disease Virus Infection and Tumor Formation in Chickens [PDF]

Viruses
Marek’s Disease Virus (MDV) is a highly contagious pathogen in chickens, resulting in immunosuppression and T-cell lymphomas. Understanding the role of host cytokines in MDV pathogenesis is crucial for developing effective interventions.
Nitish Boodhoo, Katherine Blake, Fatemeh Fazel, Janan Shoja Doost, Shayan Sharif   +4 more
doaj   +2 more sources

Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus [PDF]

Frontiers in Microbiology
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been identified.
Chengfei Ge, Hangqiong Lu, Jinze Han, Guorong Sun, Shihao Li, Xingge Lan, Yongzhen Liu, Mengmeng Yu, Xinyun Hu, Mingxue Hu, Xiaole Qi, Hongyu Cui, Yulu Duan, Suyan Wang, Yuntong Chen, Xiaomei Wang, Xiaomei Wang, Yanping Zhang, Yulong Gao, Changjun Liu   +19 more
doaj   +2 more sources

Comparative transcriptomic analysis of chicken immune organs affected by Marek’s disease virus infection at latency phases [PDF]

Frontiers in Physiology
Over the past decades, MDV has dramatically evolved towards more virulent strains and remains a persistent threat to the world’s poultry industry.
Yi Ding, John Dunn, Huanmin Zhang, Keji Zhao, Jiuzhou Song   +4 more
doaj   +2 more sources