Results 31 to 40 of about 5,051 (176)

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]

, 2018
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A, Deist, Melissa S, Dekkers, Jack CM, Gallardo, Rodrigo A, Kaiser, Michael G, Kelly, Terra R, Lamont, Susan J, Zhang, Jibin, Zhou, Huaijun   +8 more
core   +3 more sources

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America [PDF]

, 2017
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus
Groenke, Nicole, He, Shulin, Jenckel, Maria, Kunec, Dusan, McMahon, Dino P., Osterrieder, Nikolaus, Spatz, Stephen J., Szpara, Moriah L., Trimpert, Jakob   +8 more
core   +1 more source

Pathogenicity of Field Marek’s Disease Virus Serotype-1 and Vaccine Efficacy Test in Chicken in Eastern Shewa Ethiopia

Veterinary Medicine: Research and Reports, 2021
Yasin Mohammed Yimer,1 Destaw Asfaw Ali,2 Belayneh Getachew Ayalew,3 Molalegne Bitew Asires,4 Esayas Gelaye3 1College of Veterinary Medicine, Samara University, Samara, Ethiopia; 2College of Veterinary Medicine and Animal Sciences, University of Gondar ...
Yimer YM, Asfaw Ali D, Getachew Ayalew B, Bitew Asires M, Gelaye E   +4 more
doaj  

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

PLoS Biology, 2021
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman   +9 more
doaj   +1 more source

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding. [PDF]

, 2015
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface
A Madrigal (7759361), AG Wrobel (7759331), C Butter (7759349), C Durant (7759334), C Hermann (7759325), EK Meziane (7759319), J Kaufman (7733951), L Mears (7759328), LL Nielsen (7759337), M Harrison (7748669), N Ternette (7759343), P Chappell (7759316), P Roversi (7719092), R Duggleby (7759358), S Buus (7759340), SM Lea (7719098), T Ahyee (7759355), V Nair (7759352), W Mwangi (7759346), Ł Magiera (7759322)   +19 more
core   +6 more sources

Deletion of the meq gene significantly decreases immunosuppression in chickens caused by pathogenic marek's disease virus

Virology Journal, 2011
Background Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens, resulting in immunosuppression, which is considered to be an integral aspect of the pathogenesis of Marek's disease (MD).
Cui Zhizhong, Zhao Peng, Su Shuai, Sun Aijun, Li Yanpeng, Zhu Hongfei   +5 more
doaj   +1 more source

Microsatellite Markers Associated with Resistance to Marek’s Disease in Commercial Layer Chickens [PDF]

, 2005
The objective of the current study was to identify QTL conferring resistance to Marek\u27s disease (MD) in commercial layer chickens. To generate the resource population, 2 partially inbred lines that differed in MD-caused mortality were intermated to ...
Cheng, H. H., Dekkers, Jack, Fulton, J. E., Koehler, Kenneth, Lamont, Susan, Lamont, Susan, Lipkin, E., McElroy, Joseph, O'Sullivan, Neil, Soller, M., Zhang, W.   +10 more
core   +3 more sources

Isolation and analysis of a very virulent Marek’s disease virus strain in China [PDF]

, 2013
BACKGROUND: A severe MD was broken out at a farm in Shandong, China, despite FC126 vaccination of the chickens at 1-day-old. The mortality of the flocks reached up to 38.3%.
Hongchao Ma, Hu Shan, Jianlin Wang, Lijuan Zhang, Linlin Chen, Zhenhua Gong, Zhiliang Wang   +6 more
core   +1 more source

A Novel Effective and Safe Vaccine for Prevention of Marek’s Disease Caused by Infection with a Very Virulent Plus (vv+) Marek’s Disease Virus

Vaccines, 2021
Marek’s disease virus (MDV) is a highly contagious alphaherpesvirus that causes rapid onset lymphoma in chickens. Marek’s disease (MD) is effectively controlled using vaccination; however, MDV continues to break through vaccinal immunity, due to the ...
Yifei Liao, Sanjay M. Reddy, Owais A. Khan, Aijun Sun, Blanca Lupiani   +4 more
doaj   +1 more source

A full UL13 open reading frame in Marek’s disease virus (MDV) is dispensable for tumor formation and feather follicle tropism and cannot restore horizontal virus transmission of rRB-1B in vivo [PDF]

, 2007
peer reviewedMarek’s disease virus (MDV) is an oncogenic alphaherpesvirus that is highly contagious in poultry. Recombinant RB-1B (rRB-1B) reconstituted from an infectious genome cloned as a bacterial artificial chromosome (BAC) is unable to spread ...
Beaumont, Catherine, Blondeau, Caroline, Chbab, Najet, Courvoisier, Katia, Denesvre, Caroline, Osterrieder, Nikolaus, Vautherot, Jean-Francois   +6 more
core   +4 more sources