Results 11 to 20 of about 542,796 (218)

The Role of Artificial Intelligence in Herpesvirus Detection, Transmission, and Predictive Modeling: With a Special Focus on Marek’s Disease Virus [PDF]

Pathogens
Herpesvirus infections, including herpes simplex virus (HSV), Epstein–Barr virus (EBV), and cytomegalovirus (CMV), present significant challenges in diagnosis, treatment, and transmission control.
Haji Akbar
doaj   +2 more sources

Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus [PDF]

Viruses
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence.
Jumpei Sato, Yoshinosuke Motai, Shunsuke Yamagami, Aoi Kurokawa, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +11 more
doaj   +2 more sources

Overexpression of Interleukin-17 Modulates Responses to Marek’s Disease Virus Infection and Tumor Formation in Chickens [PDF]

Viruses
Marek’s Disease Virus (MDV) is a highly contagious pathogen in chickens, resulting in immunosuppression and T-cell lymphomas. Understanding the role of host cytokines in MDV pathogenesis is crucial for developing effective interventions.
Nitish Boodhoo, Katherine Blake, Fatemeh Fazel, Janan Shoja Doost, Shayan Sharif   +4 more
doaj   +2 more sources

Comparative transcriptomic analysis of chicken immune organs affected by Marek’s disease virus infection at latency phases [PDF]

Frontiers in Physiology
Over the past decades, MDV has dramatically evolved towards more virulent strains and remains a persistent threat to the world’s poultry industry.
Yi Ding, John Dunn, Huanmin Zhang, Keji Zhao, Jiuzhou Song   +4 more
doaj   +2 more sources

Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus [PDF]

Frontiers in Microbiology
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been identified.
Chengfei Ge, Hangqiong Lu, Jinze Han, Guorong Sun, Shihao Li, Xingge Lan, Yongzhen Liu, Mengmeng Yu, Xinyun Hu, Mingxue Hu, Xiaole Qi, Hongyu Cui, Yulu Duan, Suyan Wang, Yuntong Chen, Xiaomei Wang, Xiaomei Wang, Yanping Zhang, Yulong Gao, Changjun Liu   +19 more
doaj   +2 more sources

Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines

Viruses, 2023
As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-ling Liu, M. Teng, Luping Zheng, F. Zhu, Shuai Ma, Lin-Yan Li, Zhi-Hui Zhang, S. Chai, Yongxiu Yao, Jun Luo   +9 more
semanticscholar   +1 more source

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Journal of Virology, 2022
Circular RNAs (circRNAs) were rediscovered in recent years both in physiological and pathological contexts, such as in cancer. Viral circRNAs are encoded by at least two human herpesviruses, the Epstein Barr virus and the Kaposi’s Sarcoma-associated ...
Alexis S Chasseur, Gabrielle Trozzi, Céline Istasse, Astrid Petit, P. Rasschaert, C. Denesvre, B. Kaufer, L. D. Bertzbach, B. Muylkens, Damien Coupeau   +9 more
semanticscholar   +1 more source

Phenotypic characterization of gamma delta (γδ) T cells in chickens infected with or vaccinated against Marek's disease virus.

Virology, 2022
Marek's disease (MD) vaccines reduce the incidence of MD but cannot control virus shedding. To develop new vaccines, it is essential to elucidate mechanisms of immunity to Marek's disease virus (MDV) infection.
Ayumi Matsuyama-Kato, H. Iseki, Nitish Boodhoo, J. Bavananthasivam, Nadiyah Alqazlan, M. F. Abdul-Careem, B. Plattner, S. Behboudi, S. Sharif   +8 more
semanticscholar   +1 more source

The Regulatory Microenvironment in Feathers of Chickens Infected with Very Virulent Marek’s Disease Virus

Viruses, 2022
Vaccines against Marek’s disease can protect chickens against clinical disease; however, infected chickens continue to propagate the Marek’s disease virus (MDV) in feather follicles and can shed the virus into the environment.
Jegarubee Bavananthasivam, Nadiyah Alqazlan, Mohammadali Alizadeh, Ayumi Matsuyama-Kato, Jake Astill, Raveendra R. Kulkarni, Shayan Sharif   +6 more
doaj   +1 more source

Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek’s Disease Virus in Chickens With B19 and B21 MHC Haplotypes

Frontiers in Immunology, 2022
Marek’s disease virus (MDV), the etiologic agent for Marek’s disease (MD), causes a deadly lymphoproliferative disease in chickens. Causes of the well-documented association between genetically defined lines of chicken and resistance to MD remain unknown.
Nitish Boodhoo, S. Behboudi
semanticscholar   +1 more source