Results 31 to 40 of about 4,947 (174)

Deletion of the Viral Thymidine Kinase in a Meq-Deleted Recombinant Marek’s Disease Virus Reduces Lymphoid Atrophy but Is Less Protective

Microorganisms, 2021
Marek’s disease (MD) is a ubiquitous disease of domesticated chickens and its etiologic agent is the Gallid alphaherpesvirus 2 (GaHV-2), also known as Marek’s disease virus (MDV). MD is currently controlled by vaccination using live attenuated strains of
Steven J. Conrad, Eniope B. Oluwayinka, Mohammad Heidari, Jody K. Mays, John R. Dunn   +4 more
doaj   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Epstein-Barr virus-encoded RNAs (EBERs) complement the loss of the herpesvirus telomerase RNA (vTR) in virus-induced tumor formation [PDF]

, 2017
Marek’s disease virus (MDV) is an alphaherpesvirus that causes fatal lymphomas in chickens and is used as a natural virus-host model for herpesvirus-induced tumorigenesis.
Kaufer, Benedikt, Kheimar, Ahmed
core   +2 more sources

Pathogenicity of Field Marek’s Disease Virus Serotype-1 and Vaccine Efficacy Test in Chicken in Eastern Shewa Ethiopia

Veterinary Medicine: Research and Reports, 2021
Yasin Mohammed Yimer,1 Destaw Asfaw Ali,2 Belayneh Getachew Ayalew,3 Molalegne Bitew Asires,4 Esayas Gelaye3 1College of Veterinary Medicine, Samara University, Samara, Ethiopia; 2College of Veterinary Medicine and Animal Sciences, University of Gondar ...
Yimer YM, Asfaw Ali D, Getachew Ayalew B, Bitew Asires M, Gelaye E   +4 more
doaj  

Deletion of the meq gene significantly decreases immunosuppression in chickens caused by pathogenic marek's disease virus

Virology Journal, 2011
Background Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens, resulting in immunosuppression, which is considered to be an integral aspect of the pathogenesis of Marek's disease (MD).
Cui Zhizhong, Zhao Peng, Su Shuai, Sun Aijun, Li Yanpeng, Zhu Hongfei   +5 more
doaj   +1 more source

A Novel Effective and Safe Vaccine for Prevention of Marek’s Disease Caused by Infection with a Very Virulent Plus (vv+) Marek’s Disease Virus

Vaccines, 2021
Marek’s disease virus (MDV) is a highly contagious alphaherpesvirus that causes rapid onset lymphoma in chickens. Marek’s disease (MD) is effectively controlled using vaccination; however, MDV continues to break through vaccinal immunity, due to the ...
Yifei Liao, Sanjay M. Reddy, Owais A. Khan, Aijun Sun, Blanca Lupiani   +4 more
doaj   +1 more source

Modulation of Functional Activities of Chicken Heterophils by Recombinant Chicken IFN-γ [PDF]

, 2001
The objective of the present studies was to examine the in vitro effects of recombinant chicken interferon-γ (rChIFN-γ) on shape change, phagocytosis, and the oxidative/nonoxidative killing activities of day-old chicken heterophils.
B. Kaspers, E.J. Pishko, HARMON B.G., K.C. Weining, KLEIN J.B., KOGUT M.H., KOGUT M.H., LEINO L., M.H. Kogut, MERRILL G.A., SETO F., STICKLE J.F., WEINING K.C.   +12 more
core   +1 more source

A full UL13 open reading frame in Marek’s disease virus (MDV) is dispensable for tumor formation and feather follicle tropism and cannot restore horizontal virus transmission of rRB-1B in vivo [PDF]

, 2007
peer reviewedMarek’s disease virus (MDV) is an oncogenic alphaherpesvirus that is highly contagious in poultry. Recombinant RB-1B (rRB-1B) reconstituted from an infectious genome cloned as a bacterial artificial chromosome (BAC) is unable to spread ...
Beaumont, Catherine, Blondeau, Caroline, Chbab, Najet, Courvoisier, Katia, Denesvre, Caroline, Osterrieder, Nikolaus, Vautherot, Jean-Francois   +6 more
core   +4 more sources

Microsatellite Markers Associated with Resistance to Marek’s Disease in Commercial Layer Chickens [PDF]

, 2005
The objective of the current study was to identify QTL conferring resistance to Marek\u27s disease (MD) in commercial layer chickens. To generate the resource population, 2 partially inbred lines that differed in MD-caused mortality were intermated to ...
Cheng, H. H., Dekkers, Jack, Fulton, J. E., Koehler, Kenneth, Lamont, Susan, Lamont, Susan, Lipkin, E., McElroy, Joseph, O'Sullivan, Neil, Soller, M., Zhang, W.   +10 more
core   +3 more sources

Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution

Epidemics, 2018
Marek's disease virus (MDV) is a pathogen of chickens whose control has twice been undermined by pathogen evolution. Disease ecology is believed to be the main driver of this evolution, yet mathematical models of MDV disease ecology have never been ...
David A. Kennedy, Patricia A. Dunn, Andrew F. Read   +2 more
doaj   +1 more source