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A standard vaccine against Marek's disease
Comparative Immunology, Microbiology and Infectious Diseases, 1978Abstract HVT-7, the standard vaccine against MD, was prepared from HVT strain FC126 grown in fibroblast cultures from SPF embryos. Ampoules of freeze dried material were prepared from a cell free suspension of virus in a solution of SPGA. The vaccine is stored at −20°C.
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Marek's disease in turkeys: Lack of protection by vaccination
American Journal of Veterinary Research, 1982SUMMARY Herpesvirus of turkeys, a highly effective vaccine against Marek's disease (md) in chickens, was ineffective in protecting turkeys against md. Another tissue-culture attenuated vaccine virus also protected chickens, but not turkeys, from md. Intact and immunosuppressed turkey poults inoculated with herpesvirus of turkey developed a persistent ...
A K, Elmubarak +3 more
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Vaccination against Marek’s Disease
1986Marek’s disease is a serious lymphoproliferative disease of the fowl which affects most organs and tissues but has an unusual predilection for peripheral nerves. The disease varies in severity ranging in extremes from the chronic disease, in which peripheral nerve involvement and paralytic signs are the most conspicuous features, to an acute ...
L. J. N. Ross, P. M. Biggs
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A comparison of titration methods for Marek's disease vaccines
Journal of Biological Standardization, 1979Factors associated with the in vitro assay system used for the titration of Marek's disease vaccines were examined for their influence on plaque counts. Results showed that primary chick embryo fibroblasts (CEF) were more sensitive to HVT than secondary CEF and that these cells were more susceptible when approximately 24 h old at the time of infection.
R A, Nicholas +2 more
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Studies on the mechanism of vaccinal immunity to Marek's disease
Comparative Immunology, Microbiology and Infectious Diseases, 1978Abstract Current knowledge of the nature of the antigens and of the host immune responses in vaccinal immunity to Marek's disease is reviewed. It is suggested that a two-step mechanism of resistance operates. The first step involves humoral and cell-mediated responses directed against viral antigens; the second step occurs after challenge with Marek ...
L N, Payne +3 more
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Avian diseases, 1976
Viremia with turkey herpesvirus (HVT) and/or Marek's disease (MD) herpesvirus (MDHV) was examined in chickens from three different commercial flocks experiencing "vaccine breaks" following vaccination with HVT vaccine against MD. In all groups of sample chickens from the flocks, the incidence of detectable HVT viremia was significantly less in the MD ...
B. R. Cho, R. K. Balch, R. W. Hill
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Viremia with turkey herpesvirus (HVT) and/or Marek's disease (MD) herpesvirus (MDHV) was examined in chickens from three different commercial flocks experiencing "vaccine breaks" following vaccination with HVT vaccine against MD. In all groups of sample chickens from the flocks, the incidence of detectable HVT viremia was significantly less in the MD ...
B. R. Cho, R. K. Balch, R. W. Hill
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Control of Marek's Disease by Vaccination
World's Poultry Science Journal, 1973There are three types of vaccines presently available for the control of Marek's disease (MD), namely the apathogenic MD viruses that spread horizonatlly, the altered viruses that do not spread and...
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Protective Efficacy of Marek’s Disease Vaccines
2001For the past 30 years, the poultry industry has relied on a series of avirulent or attenuated live virus vaccines to provide protection to young chickens against natural challenge with field strains of Marek’s disease (MD). This strategy has been unusually effective.
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Vaccine, 2016
Marek's disease virus (MDV) induces tumors and severe immunosuppression in chickens. MDV-induced immunosuppression (MDV-IS) is very complex and difficult to study. In particular, the late MDV-IS (late-MDV-IS) is of great concern since it can occur in the absence of lymphoid organ atrophy or gross tumors.
Nik M, Faiz +4 more
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Marek's disease virus (MDV) induces tumors and severe immunosuppression in chickens. MDV-induced immunosuppression (MDV-IS) is very complex and difficult to study. In particular, the late MDV-IS (late-MDV-IS) is of great concern since it can occur in the absence of lymphoid organ atrophy or gross tumors.
Nik M, Faiz +4 more
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Production of Marek's disease vaccine.
Advances in biotechnological processes, 1990Marek's disease (MD) is one of the viral infections that attack poultry and are widespread throughout the world. Vaccination is widely used for the protection of chickens against outbreaks of MD, and commercial vaccines have been used since 1970. There are vaccines derived from three avian herpesvirus serotypes which are propagated in CEF or DEF cell ...
D, Ben-Nathan, S, Lustig
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