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Developments in biological standardization, 1983
Marek's disease (MD) vaccines have been in almost universal use since the early 1970's and constitute the first effective practical means for the control of any neoplastic disease in man or animals. Five types have been described: 1) attenuated variants of oncogenic strains (Serotype 1) of Marek's disease virus (MDV) produced by serial passage in ...
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Marek's disease (MD) vaccines have been in almost universal use since the early 1970's and constitute the first effective practical means for the control of any neoplastic disease in man or animals. Five types have been described: 1) attenuated variants of oncogenic strains (Serotype 1) of Marek's disease virus (MDV) produced by serial passage in ...
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Protection against Marek's Disease by Vaccination with a Herpesvirus of Turkeys
Avian Diseases, 1970SUMMARY Studies were conducted to determine whether a herpesvirus isolated from turkeys (HVT) would protect chickens against subsequent challenge with the virulent JM strain of Marek's disease herpesvirus (MDHV). HVT administered intra-abdominally at doses as low as 600 plaque-forming units per one-day-old chick gave protection against Marek's disease (
W, Okazaki +2 more
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Recombinant vaccines against Marek's disease
Avian Pathology, 1998Novel approaches to vaccination against very virulent (vv) strains of Marek's disease virus (MDV) are discussed. Fowlpox virus (FPV) and herpesvirus of turkeys (HVT) recombinants expressing MDV antigens have been constructed. It has been shown that glycoprotein B of MDV serotype 1 (gB1) is an effective immunogen which is particularly important for ...
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Bursal Lesions in Chickens Inoculated with Marek's Disease Vaccines
Avian Diseases, 1972The effects on the bursa of Fabricius (BF) of a herpesvirus, isolated from turkeys (HVT) and used as a vaccine in chickens for the prevention of Marek's disease (MD), were examined. In 25 HVT-vaccinated unchallenged chickens, histologic examination of the BF failed to reveal detectable lesions.
O J, Fletcher, C S, Eidson, S H, Kleven
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Marek's disease--the disease and its prevention by vaccination.
The British journal of cancer. Supplement, 1976Marek's disease (MD) is a common lymphoproliferative disease of the domestic chicken caused by a cell associated herpesvirus. Vaccines used for the prophylaxis of MD have been derived from non-pathogenic field Marek's disease virus (MDV), pathogenic MDV and the herpesvirus of turkeys (HVT).
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Role of Tumor Antigen in Vaccine Protection in Marek’s Disease
1977Chickens vaccinated with HVT developed lymphoproliferative lesions and a cell-mediated immune response to MATSA. These observations are considered in view of the overall mechanism of vaccine protection in MD. A mechanism of vaccine action is proposed that suggests that MATSA immunity in vaccinated chickens may play an important role in protection.
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Marek's disease--survey on vaccination failures.
Developments in biological standardization, 1983Twelve years after the initial development of efficacious vaccines against Marek's disease--prepared mostly from HVT--and their subsequent use on a large scale, there is a general opinions that failures have been increasing in incidence and in severity.
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Field trials with an attenuated Marek's disease vaccine
Veterinary Record, 1971G, Meulemans +3 more
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Successful control of Marek's disease by vaccination.
Developments in biologicals, 2005Marek's disease (MD) is a neoplastic disease of poultry caused by the highly contagious Marek's disease virus (MDV). Vaccination with live attenuated vaccines forms the cornerstone of the current MD control programmes. The widespread use of the vaccines in the last 30 years has significantly reduced the losses from MD.
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