Results 161 to 170 of about 2,016 (189)
Maresin-1 and Inflammatory Disease [PDF]
International Journal of Molecular Sciences, 2022 Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified.
Natsuko Saito-Sasaki +2 more
exaly +4 more sources
Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice [PDF]
British Journal of Pharmacology, 2022 Background and PurposePulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear.Experimental ApproachThe serum Maresin 1 concentration was ...
Hui Li, Haijian Cai, Aaron Scott
exaly +4 more sources
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Maresin-1 resolution with RORα and LGR6
Progress in Lipid Research, 2020Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
Dong-Soon Im
exaly +3 more sources
Stereoselective synthesis of maresin 1
Tetrahedron Letters, 2015Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Jørn Eivind Tungen +2 more
exaly +2 more sources
Synthesis of maresin 1 and (7S)-isomer
Tetrahedron Letters, 2014Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa +2 more
exaly +2 more sources
Relationship between pancreatic cancer and Maresin 1
Journal of Current Hematology & Oncology Research, 2023Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol +5 more
openaire +1 more source
Total Synthesis and Bioactivities of Two Proposed Structures of Maresin
Chemistry – An Asian Journal, 2010AbstractMaresin is a potent anti‐inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7‐epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF3‐mediated alkyne attack on the epoxide, chiral titanium complex ...
Kenji, Sasaki +4 more
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Serum Maresin 1 levels in idiopathic acute anterior uveitis patients
Journal Français d'Ophtalmologie, 2022The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA).
F.C. Gül +4 more
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Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3
Journal of Dental Research, 2022Periodontal disease is a significant public health problem worldwide. Excess unresolved chronic inflammation destroys the periodontal tissues that surround and support the teeth, and efforts to control inflammation by removal of bacterial deposits on the teeth have limited long-term impact.
A. Rakian +4 more
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Identification of Metabolites of Maresin 1 in Human Neutrophils
The FASEB Journal, 2017The resolution of inflammation, once considered to be rather passive, is now understood to be a complex, regulated process. One of the components in this process is the action of pro‐resolving lipid mediators, including lipoxins, resolvins, protectins and maresins.
Miguel A Gijón +4 more
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