Results 91 to 100 of about 1,734 (194)

Refractory/Resistant Cytomegalovirus Infection in Transplant Recipients: An Update

Viruses
Despite the significant progress made, CMV infection is one of the most frequent infectious complications in transplant recipients. CMV infections that become refractory or resistant (R/R) to the available antiviral drugs constitute a clinical challenge ...
Léna Royston, Genovefa A. Papanicolaou, Dionysios Neofytos   +2 more
doaj   +1 more source

Resistance of Human Cytomegalovirus to Cyclopropavir Maps to a Base Pair Deletion in the Open Reading Frame of \u3cem\u3eUL97\u3c/em\u3e [PDF]

, 2013
Human cytomegalovirus (HCMV) is a widespread pathogen in the human population, affecting many immunologically immature and immunocompromised patients, and can result in severe complications, such as interstitial pneumonia and mental retardation.
Borysko, Katherine Z., Drach, John C., Gentry, Brian G., Hall, Ellie D., Kamil, Jeremy P., Vollmer, Laura E., Zemlicka, Jiri   +6 more
core   +1 more source

The effective multiplicity of infection for HCMV depends on the activity of the cellular 20S proteasome

Journal of Virology
Human cytomegalovirus (HCMV) is a betaherpesvirus capable of infecting numerous cell types and persisting throughout an infected individual’s life. Disease usually occurs in individuals with compromised or underdeveloped immune systems.
Katie M. Cataldo, Kathryn L. Roche, Christopher E. Monti, Ranjan K. Dash, Eain A. Murphy, Scott S. Terhune   +5 more
doaj   +1 more source

Drug Combinations for Treatment of Emerging and Re-emerging Viral Infections [PDF]

, 2022
Den pågående SARS-CoV-2 pandemien er kun en av mange virale trusler som viser at det er behov for redskap for å bekjempe kommende og gjenkommende virusinfeksjoner.
Myhre, Vegard
core  

Decoding the Landscape of Cytomegalovirus Research in Liver Transplantation: An In-Depth Analysis

High Yield Medical Reviews
Introduction: Cytomegalovirus (CMV), a prevalent viral infection post-liver transplantation, significantly influences transplant outcomes. This bibliometric analysis explores the evolving landscape of CMV-related research in liver transplantation ...
Laurie Hung, Haneen Al-Abdallat, Aasem Rawshdeh, Esra’a Rasmi Al-Zghoul, Amani Al-Rawashdeh, Mohammad Alzoubi, Badi Rawashdeh   +6 more
doaj   +1 more source

Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins

Viruses, 2016
The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber, Alexandra Kraut, Eileen Socher, Heinrich Sticht, Anna Reichel, Thomas Stamminger, Bushra Amin, Yohann Couté, Corina Hutterer, Manfred Marschall   +9 more
doaj   +1 more source

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity [PDF]

The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type 2 (SARS-CoV-2 or COVID-
Brückner, Nadine, Eickhoff, Jan, Hahn, Friedrich, Jeon, Yeejin, Kaufer, Benedikt B., Kicuntod, Jintawee, Kim, Jaeseung, Klebl, Bert, Marschall, Manfred, Nam, Kiyean, Neipel, Frank, Schütz, Martin, Seo, Mooyoung, Tillmanns, Julia, Wagner, Sabrina, Wangen, Christina, Yu, DongHoon   +16 more
core   +1 more source

Degree-based topological indices and QSPR analysis of Cytomegalovirus drugs

International Journal of Mathematics for Industry
This study examines several drugs employed in treating Cytomegalovirus (CMV) infections, including Cidofovir, Foscarnet, Ganciclovir, Maribavir, and Valganciclovir.
H. M. Nagesh
doaj   +1 more source

Improved process for the preparation of 5,6-dichloro-1H-benzo[d] imidazol-2(3H)-one [PDF]

The present disclosure relates to an improved process for the preparation of 5,6-dichloro-1H-benzo[d] imidazol-2(3H)-one of formula-1 which is the key intermediate for Maribavir.
, MSN Laboratories Private Limited, R&D Center
core   +1 more source

SP05 | MARIBAVIR AS ANTI-CYTOMEGALOVIRUS TREATMENT IN REFRACTORY OR RESISTANT DISEASES IN A NON-TRANSPLANT SETTING

Haematologica
Introduction: CMV infection can be life-threatening in immunocompromised patients. In the setting of allo-HSCT, different treatment strategies exist for refractory or resistant CMV disease.
U. Pizzano, G. De Cicco, D. Schiavo, E. Scarpa, M. Stanzani.   +4 more
doaj