Results 61 to 70 of about 1,734 (194)

Management of Cytomegalovirus Infections in the Era of the Novel Antiviral Players, Letermovir and Maribavir

Infectious Disease Reports
Cytomegalovirus (CMV) infections may increase morbidity and mortality in immunocompromised patients. Until recently, standard antiviral drugs against CMV were limited to viral DNA polymerase inhibitors (val)ganciclovir, foscarnet and cidofovir with a ...
Jocelyne Piret, Guy Boivin
doaj   +1 more source

Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers

Pharmaceutics, 2023
Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations.
Markus Wild, Dubravka Karner, Jan Eickhoff, Sabrina Wagner, Jintawee Kicuntod, William Chang, Peter Barry, Stipan Jonjić, Tihana Lenac Roviš, Manfred Marschall   +9 more
doaj   +1 more source

Phenotyping of N -acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? [PDF]

, 2018
Objectives: Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites.
Fuhr, Uwe, Jetter, Alexander, Kinzig, Martina, Rodamer, Michael, Sörgel, Fritz, Tomalik-Scharte, Dorota   +5 more
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Cytomegalovirus drug resistance mutations in transplant recipients with suspected resistance [PDF]

, 2023
Resistant CMV infections are challenging complications after SOT and HSCT. Prompt recognition of ARMs is imperative for appropriate therapy. 108 plasma samples from 96 CMV + transplant recipients with suspected resistance were analysed in CNM in a ...
Gonzalez-Jimenez, Irene, Recio Huertas, Vanessa, Tarrago Asensio, David   +2 more
core   +1 more source

Large Language Models for Clinical Trial Protocol Assessments

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 393-402, February 2026.
The purpose was to evaluate the utility of large language models (LLMs) for reviewing the statistical analysis plan (SAP) and pharmacokinetics–pharmacodynamics (PK–PD) components of clinical trial protocols. Clinical trial protocols and SAPs were obtained from clinicaltrials.gov for a testbed of 15 small‐molecule drugs, biologics, and global antibiotic
Euibeom Shin, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Case Report: Approaches for managing resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplantation recipients

Frontiers in Pediatrics
The instructional case is a pediatric haploidentical TCRαβ+/CD19+ depleted allogeneic hematopoietic cell transplantation recipient who developed early onset CMV infection, which was complicated by resistant CMV (both UL97 and UL54) and successfully ...
Eunkyung Song, Eunkyung Song
doaj   +1 more source

Novel Antiviral Compound shows in-vivo efficacy against Cytomegalovirus [PDF]

, 2007
Widespread use of Ganciclovir (GCV) therapy has led to resistant strains of cytomegalovirus (CMV), prompting development of new antiviral compounds. A novel duplex compound of Zidovudine and Foscarnet (N3) has shown excellent in-vitro activity against ...
Capone, Jesse
core   +1 more source

In vitro assessment of the combined effect of letermovir and sirolimus on cytomegalovirus replication [PDF]

, 2023
Introduction. Letermovir (LMV) is used for prophylaxis of cytomegalovirus (CMV) reactivation and end-organ disease in adult CMV-seropositive allogeneic hematopoietic stem cell transplant recipients (allo-HSCT).
Aguilar, Cristóbal, Albert, Eliseo, Giménez, Estela, Gozalbo Rovira, Roberto Vicente, Guerreiro, Manuel, Navarro Ortega, David, Piñana, José Luis, Solano Vercet, Carlos   +7 more
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Intestinal and Multivisceral Transplantation: Where We Stand Today

Pediatric Transplantation, Volume 30, Issue 1, January 2026.
ABSTRACT Intestinal and multivisceral transplantation has evolved from an experimental to a life‐saving procedure for children and adults with complications of gut failure (GF). Suboptimal long‐term outcomes of transplant elicit recent advances in surgical and medical gut rehabilitation along with the introduction of glucagon‐like peptide‐2 (GLP‐2 ...
Mohamed Maklad, Mohammed Osman, Mariam Ismail, Tetsuya Tajima, Kadakkal Radhakrishnan, Masato Fujiki   +5 more
wiley   +1 more source

Diseño, síntesis y caracterización estructural de compuestos derivados de 2-amino-propano-1,3-diol potencialmente activos como antivirales [PDF]

, 2019
Los adenovirus (AdV) son virus eucariotas con 36000 pares de bases, producen infecciones que son muy comunes y se dan durante todo el año. Las poblaciones susceptibles a la infección por adenovirus (AdV) incluyen niños, pacientes inmunocomprometidos y ...
Muriana Camacho, Claudia
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