Results 61 to 70 of about 357,348 (338)

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

Biochemical Pharmacology, 2017
The Mas receptor is involved in the angiotensin (Ang)-(1-7) vasodilatory actions by increasing nitric oxide production (NO). We have previously demonstrated an increased production of Ang-(1-7) in human umbilical vein endothelial cells (HUVEC) exposed to estradiol (E2), suggesting a potential cross-talk between E2 and the Ang-(1-7)/Mas receptor axis ...
Sobrino A, Vallejo S, Novella S, Lazaro-Franco M, Mompeon A, Bueno-Beti C, Walther T, Sanchez-Ferrer C, Peiro C, Hermenegildo C   +9 more
openaire   +4 more sources

Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]

PLoS ONE, 2013
Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira, Lívia Corrêa Barroso, Angélica Thomáz Vieira, Daniel Cisalpino, Cristiano Xavier Lima, Michael Bader, Rosa Maria Esteves Arantes, Robson Augusto Souza Dos Santos, Ana Cristina Simões-E-Silva, Mauro Martins Teixeira   +9 more
doaj   +1 more source

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. [PDF]

PLoS ONE, 2009
Angiotensin (Ang) II mediates pathophysiologial changes in the kidney. Ang-(1-7) by interacting with the G protein-coupled receptor Mas may also have important biological activities.In this study, renal deficiency for Mas diminished renal damage in ...
Vanesa Esteban, Silvia Heringer-Walther, Anja Sterner-Kock, Ron de Bruin, Sandra van den Engel, Yong Wang, Sergio Mezzano, Jesus Egido, Heinz-Peter Schultheiss, Marta Ruiz-Ortega, Marta Ruiz-Ortega, Thomas Walther   +11 more
doaj   +1 more source

G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor [PDF]

Circulation, 2005
Background— We previously identified the G-protein–coupled receptor Mas, encoded by the Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); however, the receptor is also suggested to be involved in actions of angiotensin II.
Kostenis, Evi, Milligan, Graeme, Christopoulos, Arthur, Sanchez-Ferrer, Carlos F, Heringer-Walther, Silvia, Sexton, Patrick M, Gembardt, Florian, Kellett, Elaine, Martini, Lene, Vanderheyden, Patrick, Schultheiss, Heinz-Peter, Walther, Thomas   +11 more
openaire   +3 more sources

CoQ10 augments candesartan protective effect against tourniquet-induced hind limb ischemia-reperfusion: Involvement of non-classical RAS and ROS pathways

Saudi Pharmaceutical Journal, 2021
Tourniquet is a well-established model of hind limb ischemia–reperfusion (HLI/R) in rats. Nevertheless, measures should be taken to alleviate the expected injury from ischemia/ reperfusion (I/R).
Azza S. Awad, Mahmoud Nour El-Din, Rehab Kamel   +2 more
doaj   +1 more source

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation [PDF]

, 2013
Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist.
A Papi, A van de Stolpe, AC Palmenberg, Alan Carruthers, Alexandra Nikonova, Alison Humbles, AM Randi, Andrew J. Leishman, Andrew Pekosz, CR Uncapher, D Wat, DC Pevear, DE Staunton, DJ Jackson, DJ Jackson, DJ Jackson, FG Hayden, FG Hayden, Gary R. McLean, J Bizzintino, J Corren, J Garbino, J Las Heras, JE Gern, JE Prince, Jie Zhu, JM Greve, Katherine A. Vousden, Katie Bernard, KB Weiss, KG Nicholson, Leila Gogsadze, Matthew A. Sleeman, Michael Dymond, MS Diamond, Musa Khaitov, Nathan W. Bartlett, Nicholas Glanville, NW Bartlett, P Mallia, Q Wang, Qing Zhu, R Fleischer, Rebecca Dunmore, RF Lemanske Jr, RH Dougherty, RM Owens, Roland Kolbeck, Ross P. Walton, RR Turner, Sebastian L. Johnston, SK Lau, SL Binford, Stephanie Traub, Ted Wells, Weidong Hao, YA Bochkov   +56 more
core   +3 more sources

Hydronephrosis alters cardiac ACE2 and Mas receptor expression in mice

Journal of the Renin-Angiotensin-Aldosterone System, 2015
Introduction: Hydronephrosis is characterized by substantial loss of tubules and affects renin secretion in the kidney. However, whether alterations of angiotensin-converting enzyme (ACE), ACE2 and Mas receptor in the heart are observed in hydronephrosis is unknown.
Yanling, Zhang, Lulu, Ma, Junyan, Wu, Tingting, Chen   +3 more
openaire   +2 more sources

Role of the receptor Mas in macrophage-mediated inflammation in vivo [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceThe alternative renin–angiotensin system pathway, the angiotensin (Ang)-(1–7)/Mas axis, may counterbalance Ang II-mediated proinflammatory effects. To investigate the role of the Ang-(1–7)/Mas axis in immune cell function and inflammatory diseases in vivo, we used two different chronic inflammatory animal models.
Anna, Hammer, Guang, Yang, Juliane, Friedrich, Agnes, Kovacs, De-Hyung, Lee, Katharina, Grave, Stefanie, Jörg, Natalia, Alenina, Janina, Grosch, Jürgen, Winkler, Ralf, Gold, Michael, Bader, Arndt, Manzel, Lars C, Rump, Dominik N, Müller, Ralf A, Linker, Johannes, Stegbauer   +16 more
openaire   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

The expression of Mas-receptor of the renin-angiotensin system in the human eye [PDF]

, 2015
The local renin-angiotensin system has been held to be expressed in many organs, including the eye. It has an important role in the regulation of local fluid homeostasis, cell proliferation, fibrosis, and vascular tone.
Kalesnykas, G., Uusitalo, H., Vaajanen, A., Vapaatalo, H.   +3 more
core   +1 more source