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Signal Amplification for Imaging Mass Cytometry
Bioconjugate Chemistry, 2019 An enzyme-catalyzed reporter deposition stain has been developed for Imaging Mass Cytometry (IMC). The reagent consists of an alkaline phosphatase substrate tethered to a tellurophene which serves as reporter group for mass cytometry. Upon phosphate hydrolysis, a quinone methide is released which covalently labels local nucleophiles. This strategy is a
Rahul Rana +3 more
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Ruthenium counterstaining for imaging mass cytometry
The Journal of Pathology, 2018 AbstractImaging mass cytometry is a novel imaging modality that enables simultaneous antibody‐based detection of >40 epitopes and molecules in tissue sections at subcellular resolution by the use of isotopically pure metal tags. Essential for any imaging approach in which antigen detection is performed is counterstaining, which reveals the overall ...
Catena, Raúl +2 more
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Mass Cytometry, Imaging Mass Cytometry, and Multiplexed Ion Beam Imaging Use in a Clinical Setting
Clinics in Laboratory Medicine, 2021Mass cytometry (MC), imaging mass cytometry (IMC), and multiplexed ion beam imaging (MIBI) represent a new generation of tools to understand increasingly complex systems. Although these technologies differ in their intended applications, with MC being most similar to flow cytometry, and IMC/MIBI being similar to immunohistochemistry, they all share a ...
Raymond D Devine, Gregory K Behbehani
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Highly multiparametric analysis by mass cytometry
Journal of Immunological Methods, 2010This review paper describes a new technology, mass cytometry, that addresses applications typically run by flow cytometer analyzers, but extends the capability to highly multiparametric analysis. The detection technology is based on atomic mass spectrometry.
Olga Ornatsky +2 more
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An introduction to mass cytometry: fundamentals and applications
Cancer Immunology, Immunotherapy, 2013Mass cytometry addresses the analytical challenges of polychromatic flow cytometry by using metal atoms as tags rather than fluorophores and atomic mass spectrometry as the detector rather than photon optics. The many available enriched stable isotopes of the transition elements can provide up to 100 distinguishable reporting tags, which can be ...
Scott D Tanner +2 more
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Chemical Reviews, 2023
Mass cytometry (cytometry by time-of-flight detection [CyTOF]) is a bioanalytical technique that enables the identification and quantification of diverse features of cellular systems with single-cell resolution. In suspension mass cytometry, cells are stained with stable heavy-atom isotope-tagged reagents, and then the cells are nebulized into an ...
Loryn P. Arnett +8 more
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Mass cytometry (cytometry by time-of-flight detection [CyTOF]) is a bioanalytical technique that enables the identification and quantification of diverse features of cellular systems with single-cell resolution. In suspension mass cytometry, cells are stained with stable heavy-atom isotope-tagged reagents, and then the cells are nebulized into an ...
Loryn P. Arnett +8 more
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Advances in Clinical Mass Cytometry
Clinics in Laboratory Medicine, 2023The advent of high-dimensional single-cell technologies has enabled detection of cellular heterogeneity and functional diversity of immune cells during health and disease conditions. Because of its multiplexing capabilities and limited compensation requirements, mass cytometry or cytometry by time of flight (CyTOF) has played a superior role in immune ...
Abhishek, Koladiya, Kara L, Davis
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Cytometry of Mass for Murine Immunoprofiling
2022Mass cytometry or cytometry by time-of-flight (CyTOF) is a multi-parametric analytical tool that is commonly used for simultaneous detection of more than 50 markers present either on the surface or inside the cytoplasm or nucleus of the cell. It utilizes metal-tagged antibodies and offers numerous advantages over traditional immunophenotyping ...
Vidhi, Chandra +2 more
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