Results 21 to 30 of about 42,413 (216)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

WATER DEFICIT OF SPRING BARLEY PLANTS AS ONE OF THE DROUGHT TOLERANCE TRAITS

Зерновое хозяйство России, 2018
The article gives the data about the amount of water deficit (WD) of spring barley in different periods of genesis under various growing conditions. There have been selected the varieties (‘Leon’, ‘Zernogradsky 244’, ‘Zhedry’, ‘Sokol’) with a minimum ...
N. N. Anisimova, E. V. Ionova
doaj   +2 more sources

Formation of productivity of binary and single-species cenosis in the conditions of the Western Forest-Steppe

Передгірне та гірське землеробство і тваринництво, 2022
The effectiveness of certain elements of the technology for growing binary cenosis of grain crops (oat, triticale) and grain-legume (vetch, lupine) crops in the soil and climatic conditions of the Western Forest-Steppe was evaluated.
N. М. RUDАVSКА, H. S. КОNYК, А. М. SHUVАR, L. L. BЕHЕN, О. F. ТYМCHYSHYN, H. М. DОRОТА   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Formation of yield and sowing qualities of winter wheat seeds under the influence of microfertilizers in the soil and climatic conditions of the forest-steppe of Western Ukraine

Agricultural Science, 2019
The present study investigated the effect of chelated forms of microfertilizers applied in the tillering-shooting phase on the background of mineral nutrition (N90P90K90) with the phased application of nitrogen in stages IV and VII of organogenesis on ...
VOLOSCHUK Ihor , VOLOSCHUK Olexandra , HLYVA Valentyna , MARUKHNYAK Andriy   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Winter oilseed rape (Brassica napus L.) yield components in agro-ecological conditions of Banja Luka region [PDF]

Agroznanje, 2017
Due to its numerous agricultural and industrial purposes, oilseed rape is a very important species. The total production of oilseed rape in the Republic of Srpska is faced with noticeable variation throughout years, with an increase in last three years ...
Kondić Danijela, Hajder Đurađ, Marinković Saša, Nožinić Miloš   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Crowding as an Agronomic Factor Determining the Development of Plants and the Productivity of Linseed (Linum usitatissimum L.)

Journal of Natural Fibers, 2020
Nine sowing densities of linseed were compared in a two-year experiment. Self-regulation of the density of a linseed stand resulted in a differentiated branching of the plants.
Tadeusz Zając, Agnieszka Klimek-Kopyra, Jerzy Mańkowski, Ryszard Mazurek, Andrzej Oleksy, Jacek Strojny   +5 more
doaj   +1 more source