Results 21 to 30 of about 42,739 (220)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

EVALUATION OF THE ADAPTIVE POTENTIAL OF VARIETIES AND LINES OF WINTER MILD WHEAT BY THE PARAMETER "MASS OF 1000 SEEDS" IN THE CONDITIONS OF THE RESEARCH CENTER OF THE BASHKIR STATE AGRARIAN UNIVERSITY

Vestnik Bashkir State Agrarian University
Winter wheat is one of the most important, valuable, and high-yield grain crops. The purpose of this study was to determine the parameters of ecological plasticity and stability of the "1000-grain weight" trait in varieties and lines of winter soft wheat under the conditions of the Research Center of the Bashkir State Agrarian University. The object of
Igor Yu. Kuznetsov, Rail R. Alimgafarov, Nadezhda S. Anokhina, Elmira R. Dautova, Ragida Sh. Irgalina   +4 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

WATER DEFICIT OF SPRING BARLEY PLANTS AS ONE OF THE DROUGHT TOLERANCE TRAITS

Зерновое хозяйство России, 2018
The article gives the data about the amount of water deficit (WD) of spring barley in different periods of genesis under various growing conditions. There have been selected the varieties (‘Leon’, ‘Zernogradsky 244’, ‘Zhedry’, ‘Sokol’) with a minimum ...
N. N. Anisimova, E. V. Ionova
doaj   +2 more sources

Formation of productivity of binary and single-species cenosis in the conditions of the Western Forest-Steppe

Передгірне та гірське землеробство і тваринництво, 2022
The effectiveness of certain elements of the technology for growing binary cenosis of grain crops (oat, triticale) and grain-legume (vetch, lupine) crops in the soil and climatic conditions of the Western Forest-Steppe was evaluated.
N. М. RUDАVSКА, H. S. КОNYК, А. М. SHUVАR, L. L. BЕHЕN, О. F. ТYМCHYSHYN, H. М. DОRОТА   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Formation of yield and sowing qualities of winter wheat seeds under the influence of microfertilizers in the soil and climatic conditions of the forest-steppe of Western Ukraine

Agricultural Science, 2019
The present study investigated the effect of chelated forms of microfertilizers applied in the tillering-shooting phase on the background of mineral nutrition (N90P90K90) with the phased application of nitrogen in stages IV and VII of organogenesis on ...
VOLOSCHUK Ihor , VOLOSCHUK Olexandra , HLYVA Valentyna , MARUKHNYAK Andriy   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Winter oilseed rape (Brassica napus L.) yield components in agro-ecological conditions of Banja Luka region [PDF]

Agroznanje, 2017
Due to its numerous agricultural and industrial purposes, oilseed rape is a very important species. The total production of oilseed rape in the Republic of Srpska is faced with noticeable variation throughout years, with an increase in last three years ...
Kondić Danijela, Hajder Đurađ, Marinković Saša, Nožinić Miloš   +3 more
doaj   +1 more source