Results 31 to 40 of about 42,739 (220)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Crowding as an Agronomic Factor Determining the Development of Plants and the Productivity of Linseed (Linum usitatissimum L.)

Journal of Natural Fibers, 2020
Nine sowing densities of linseed were compared in a two-year experiment. Self-regulation of the density of a linseed stand resulted in a differentiated branching of the plants.
Tadeusz Zając, Agnieszka Klimek-Kopyra, Jerzy Mańkowski, Ryszard Mazurek, Andrzej Oleksy, Jacek Strojny   +5 more
doaj   +1 more source

1000 seed mass sugar beet as affected by harvesting date and plant density

Selekcija i Semenarstvo, 2003
A large number of seed sugar beet plants produced a small 1000-seed mass. Conversely, a large 1000-seed mass was obtained with a small population. The harvesting dates and trial years proved highly significant in determining the 1000-seed mass of sugar beet.
Rajić, Milorad, Marinković, Branko, Miklič, Vladimir, Panković, Lazar, Tatić, Mladen   +4 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PREDECESSORS, YIELD AND QUALITY OF WINTER WHEAT GRAIN IN THE CONDITIONS OF A FOOTHILL PART OF KABARDINO-BALKARIA

Зерновое хозяйство России, 2018
The priority of grain use is usually determined by its great social significance which allows solving the task of food supply, especially with bread. Winter wheat as a main food crop takes up 38,6% in grain production of KBR and has a major effect on the
Kh. A. Malkanduev, A. Kh. Malkandueva, R. I. Shamurzaev, R. A. Gazheva   +3 more
doaj   +2 more sources

Physical properties and mathematical modeling of melon (Cucumis melo L.) seeds and kernels

Journal of the Saudi Society of Agricultural Sciences, 2017
In the present research, some physical properties of Somsori and Varamin varieties of melon seeds and kernels were studied; three principal dimensions (length, width and thickness) of melon seeds and kernels were measured using image processing technique.
Ali Mansouri, Amir Hossein Mirzabe, Ahmad Ráufi   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of the Effects of Cultivar and Location on the Interaction of Lentil Seed Characteristics with Optimal Cooking Time

Seeds
The most important product of the lentil crop (Lens culinaris Medik) is the seeds. The main seed characteristics are their size, color, and the cooking time required to make them edible.
Dimitrios Sarakatsianos, Dimitra Polyzou, Athanasios Mavromatis, Dimitrios N. Vlachostergios, Dimitrios Gerasopoulos   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source