Results 31 to 40 of about 42,413 (216)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
1000 seed mass sugar beet as affected by harvesting date and plant density
Selekcija i Semenarstvo, 2003 A large number of seed sugar beet plants produced a small 1000-seed mass. Conversely, a large 1000-seed mass was obtained with a small population. The harvesting dates and trial years proved highly significant in determining the 1000-seed mass of sugar beet.
Rajić, Milorad +4 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Зерновое хозяйство России, 2018 The priority of grain use is usually determined by its great social significance which allows solving the task of food supply, especially with bread. Winter wheat as a main food crop takes up 38,6% in grain production of KBR and has a major effect on the
Kh. A. Malkanduev +3 more
doaj +2 more sources
SeedsThe most important product of the lentil crop (Lens culinaris Medik) is the seeds. The main seed characteristics are their size, color, and the cooking time required to make them edible.
Dimitrios Sarakatsianos +4 more
doaj +1 more source
Physical properties and mathematical modeling of melon (Cucumis melo L.) seeds and kernels
Journal of the Saudi Society of Agricultural Sciences, 2017 In the present research, some physical properties of Somsori and Varamin varieties of melon seeds and kernels were studied; three principal dimensions (length, width and thickness) of melon seeds and kernels were measured using image processing technique.
Ali Mansouri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effect of cattle manure on sunflower production and water use in two types of soil
Revista Ceres, 2013 The aim of the present study was to evaluate water consumption, use efficiency and yield components of sunflower variety Embrapa 122 V/2000 cultivated in two types of soil (Fluvissol and Haplic Luvisol) subjected to increasing doses of cattle manure. The
Francisco das Chagas Fernandes Maia Filho +4 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2022 Aim. To highlight the results of the research conducted in 2020 – 2021 aiming at studying the ffect of multi-depth and multifraction sowing of the hybrid corn seeds of the DMS Sticker mid-early maturity group on the yield when grown in the conditions ...
Oleh A. Kovalenko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source