Results 131 to 140 of about 10,756,993 (383)

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

MMP-1 activation contributes to airway smooth muscle growth and asthma severity [PDF]

, 2016
Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity.
Berger P, Catherine Reynolds, Charlotte K. Billington, Christopher Philp, David J. Jackson, Debbie Clements, Dominick E. Shaw, Hasaneen NA, Irshad Soomro, Johnson S, Karlinsky JB, Naveed S, Rajah R, Sebastian L. Johnston, Shams-un-nisa Naveed, Simon R. Johnson, Timothy W. Harrison   +16 more
core   +2 more sources

Single‐Cell RNA Sequencing Identifies MMP11+ Cancer‐Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression

Advanced Science, EarlyView.
Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu, Ting Liang, Hu Fang, Lu Fu, Dashi Deng, Xiyang Tan, Lisha Liu, Dongdong Tang, Haoxiang Zheng, Qiuxia Ding, Xiuqi Hou, Daquan Feng, Tao Tao, Song Wu   +13 more
wiley   +1 more source

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Nature Communications, 2012
Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 ...
Y. Kurashima, T. Amiya, T. Nochi, Kumiko Fujisawa, Takeshi Haraguchi, H. Iba, H. Tsutsui, Shintaro Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono   +12 more
semanticscholar   +1 more source

Mast cell-derived mediators promote murine neutrophil effector functions [PDF]

, 2017
Mast cells are able to trigger life-saving immune responses in murine models for acute inflammation. In such settings, several lines of evidence indicate that the rapid and protective recruitment of neutrophils initiated by the release of mast cell ...
Becker, Marc, Bopp, Tobias, Böhm, Livia, Codarri, Laura, Doener, Fatma, Friedrich, Pamela, Klein, Matthias, Michel, Anastasija, Radsak, Markus Philipp, Relle, Manfred, Reuter, Sebastian, Schild, Hansjörg, Schmitt, Edgar, Stassen, Michael, Taube, Christian, Tenzer, Stefan   +15 more
core  

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression

Advanced Science, EarlyView.
Migrasomes play a crucial role in endothelial‐immune interactions in atherosclerosis. This study identifies migrasomes as amplifiers in the inflammatory cascade, driving immune‐metabolic reprogramming via “migrasome‐APP‐CD74” signaling. Blocking CD74 disrupts migrasome‐mediated signaling, attenuating atherosclerosis progression.
Kangnan Zhang, Jiong Chen, Zhenhua Zhu, Hong Hu, Qinghui Zhang, Rongrong Jia, Na Wang, Shihao Xiang, Yong Zhou, Yuehong Wang, Ling Xu   +10 more
wiley   +1 more source

Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. [PDF]

, 2017
Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed ...
Alfonso, Alicia, Ashmole, Ashmole, Baba, Bischoff, Capite, Cayouette, Cayouette, Chaudhuri, Chen, Cheng, Cohen, Cruse, Derler, Dietrich, Douglas, Ennis, Estacion, Gilfillan, Gilfillan, Gordon, Hofmann, Hogan, Holowka, Hong, Kirshenbaum, Klein, Kuehn, Lee, Lewis, Liao, Liao, Liou, Ma, Martin-Avila, Medic, Metcalfe, Monet, Okayama, Ong, Ong, Ong, Pani, Pani, Prakriya, Prakriya, Pullen, Riazanski, Rice, Sabatino, Sanmugalingam, Seo, Shi, Siraganian, Souza, Souza, Storch, Suzuki, Vig, Vig, Wareham, Wareham, Washburn, Worley, Wykes, Yeh, Yuan, Zeng   +68 more
core   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells

Journal of Extracellular Vesicles, 2012
Background: Exosomes are nanosized vesicles of endocytic origin that are released into the extracellular environment by many different cells. It has been shown that exosomes from various cellular origins contain a substantial amount of RNA (mainly mRNA ...
K. Ekström, H. Valadi, M. Sjöstrand, C. Malmhäll, A. Bossios, M. Eldh, J. Lötvall   +6 more
semanticscholar   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source