Results 91 to 100 of about 7,454,476 (197)

Insulin-induced lipid body accumulation is accompanied by lipid remodelling in model mast cells

Adipocyte, 2019
Mast cell lipid bodies are key to initiation, maintenance and resolution of inflammatory responses in tissue. Mast cell lines, primary bone marrow-derived mast cells and peripheral blood basophils present a ‘steatotic’ phenotype in response to chronic ...
Johnny T. Aldan, Chad Jansen, Mark Speck, Kristina Maaetoft-Udsen, Edward A. Cordasco, Mata’Uitafa Faiai, Lori M.N. Shimoda, William E. Greineisen, Helen Turner, Alexander J. Stokes   +9 more
doaj   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Hydroxychloroquine as a novel therapeutic approach in mast cell activation diseases

, 2018
International audienceThere is no therapeutic agent approved in cutaneous mastocytosis and mast cell activation syndrome. We report the efficacy of hydroxychloroquine in four patients with cutaneous mastocytosis (n = 2) and mast cell activation syndrome (
Lavit, Michel, Espinosa, Eric, Apoil, Pol-André, Laroche, Michel, Laurent, Camille, Bulai Livideanu, Cristina, Valitutti, Salvatore, Paul, Carle, Hermine, Olivier   +8 more
core   +1 more source

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene [PDF]

, 1993
After v-H-ras expression, the interleukin 3 (IL-3)-dependent PB-3c mast cells progress in vivo to two different classes of IL-3 autocrine tumors. Class I tumors show a germline configuration of the IL-3 gene and represent more than 90% of tumors analyzed
Nair, A. P., Hirsch, H. H., A P Nair, Moroni, C., C Moroni, H H Hirsch, Hirsch HH, Nair AP, Moroni C   +8 more
core   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Release of Mast Cell Tryptase into Saliva: A Tool to Diagnose Food Allergy by a Mucosal Challenge Test? [PDF]

, 2011
Background: Our aim was to examine whether measurement of the saliva mast cell tryptase (MCT) concentrations before and after a mucosal challenge test with the offending food would be helpful in diagnosing food allergy.
Franziska Ruëff, Tanja Friedl, Matthias Kramer, Kramer, Matthias, Alexander Arnold, Rueff, Franziska, Arnold, Alexander, Przybilla, Bernhard, Bernhard Przybilla, Friedl, Tanja   +9 more
core   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Natural products AKTing on signal transduction pathways-molecules and methods [PDF]

, 2009
Natural products play an important role as source of inspiration for drug discovery and development and as tools for basic research. Isolated natural products that had shown diverse biological activity in previously published tests were analysed for ...
Kiefer, Sabine
core   +1 more source

Thrombocytosis and tumour distribution predict outcome in dogs with hepatocellular carcinoma: A multi‐institutional retrospective analysis

Veterinary Record, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is the most common canine hepatobiliary tumour. This study aimed to determine which criteria influenced outcome of HCC in a modern population of dogs across eight institutions. Methods The medical records of 106 dogs with HCC were retrospectively reviewed.
Emily A. Janik, MacKenzie A. Pellin, Dawn M. Clarke   +2 more
wiley   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source