Results 111 to 120 of about 7,454,476 (197)
The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis
Allergy, EarlyView.ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith +9 more
wiley +1 more source
, 2020 Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de MedicinaIdentificados em 1878 por Paul Ehrlich, os mastócitos são células multifuncionais complexas e um elemento-chave do sistema imunitário.
Martins, Ana Rita Ferreira
core
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
Discovering Mast Cell Activation Syndrome
Mast Cell Activation Syndrome (MCAS) is a rare disorder where inappropriate activation of mast cells causes an allergic inflammatory reaction. This project examined the immunological aspect of MCAS, clinical manifestations, current diagnostic approaches,
Holt, Jaelyn
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Symptoms of mast cell activation syndrome in functional gastrointestinal disorders
, 2019 Objectives: Mast cell involvement is evident in functional gastrointestinal disorders (FGID). FGID and mast cell activation syndrome (MCAS) are associated with multi-organ symptoms.
Olesen, Søren S; id_orcid +3 more
core +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.A large data base of colonoscopies was analysed for mast cells. The data do not show a relationship between diarrhoea and elevated mast cells in the colonic mucosa. This study provides real‐world evidence against the routine diagnostic use of colonic mast cell quantification for the evaluation of diarrhoea.
Marlena Langreiter +2 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Immunological dysfunction and mast cell activation syndrome in long COVID. [PDF]
Asia Pac Allergy, 2023 Sumantri S, Rengganis I.
europepmc +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Cancer Science, EarlyView.BTK inhibition reprograms macrophages to suppress IL‐6/IL‐8/IL‐10‐driven CRS without compromising BsAb efficacy. ABSTRACT Bispecific antibodies (BsAbs) have shown marked efficacy in relapsed or refractory (R/R) B‐cell non‐Hodgkin lymphoma (B‐NHL). However, their clinical utility is constrained by cytokine release syndrome (CRS).
Jiaowu Cao +8 more
wiley +1 more source