Results 51 to 60 of about 7,454,476 (197)

Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists

Frontiers in Cardiovascular Medicine
Mast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatology with potential manifestations in virtually every organ and tissue.
Wolfgang Taumann, Gerhard J. Molderings
doaj   +1 more source

Mast cell activation symptoms are prevalent in Long-COVID

International Journal of Infectious Diseases, 2021
Objectives: Hyper-inflammation caused by COVID-19 may be mediated by mast cell activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms. We determined prevalence/severity of MCA symptoms in LC.
Leonard B. Weinstock, Jill B. Brook, Arthur S. Walters, Ashleigh Goris, Lawrence B. Afrin, Gerhard J. Molderings   +5 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Mast cells and tryptase. Modern aspects

Медицинская иммунология, 2021
The present review considers the role of mast cells (MC) and tryptase levels in various pathological conditions in children and adults. The main causes of hypertryptasemia are presented, as well as a list of the most important stimuli that can cause ...
D. Sh. Macharadze
doaj   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Expanding the scope of mast cell disease: Does mast cell‐derived TNF play a role in immune‐mediated chronic illness and autoimmunity?

Rheumatology & Autoimmunity
Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions,
Rachel da Silveira Gorman, Iffath Unissa Syed   +1 more
doaj   +1 more source

Familial occurrence of systemic mast cell activation disease. [PDF]

PLoS ONE, 2013
Systemic mast cell activation disease (MCAD) comprises disorders characterized by an enhanced release of mast cell mediators accompanied by accumulation of dysfunctional mast cells.
Gerhard J Molderings, Britta Haenisch, Manuela Bogdanow, Rolf Fimmers, Markus M Nöthen   +4 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

The dark side of mast cells and their role in metastasis [PDF]

, 2014
Komarowska Marta Diana, Korakiewicz Gabriela, Pilaszewicz Agata, Hermanowicz Adam, Reszec Joanna, Debek Wojciech, Chyczewski Lech. The dark side of mast cells and their role in metastasis. Journal of Health Sciences. 2014;4(14):273-284. ISSN 1429-9623 /
Korakiewicz, Gabriela, Hermanowicz, Adam, Reszec, Joanna, Pilaszewicz, Agata, Debek, Wojciech, Chyczewski, Lech, Komarowska, Marta Diana   +6 more
core   +1 more source

Mast cell activation syndrome: The overdiagnosis problems

Медицинская иммунология
The incidence of mast cell activation syndrome (MCAS) has increased since first definition as a mastocytosis-like phenotype. Despite well-described criteria developed by the MCAS consortium, its growing rates have occurred in the context of multiple ...
N. V. Mikryukova, N. M. Kalinina
doaj   +1 more source