Results 31 to 40 of about 7,454,476 (197)

Non-canonical activation of PI3Kγ by Ca²⁺/PKCβ in mast cells [PDF]

, 2014
Mast cells are key effector cells in allergic disease triggering inflammation through mediator release. Allergens activate mast cells through the high-affinity receptor for IgE (FcεRI), which initiates signalling pathways that regulate the release of
Walser, Romy
core   +1 more source

Kounis Syndrome—not a Single-organ Arterial Disorder but a Multisystem and Multidisciplinary Disease

Balkan Medical Journal, 2019
Coronary symptoms associated with conditions related to mast cell activation and inflammatory cell interactions, such as those involving T-lymphocytes and macrophages, further inducing allergic, hypersensitivity, anaphylactic, or anaphylactic insults ...
Nicholas G. Kounis, Ioanna Koniari, Dimitrios Velissaris, George Tzanis, George Hahalis   +4 more
doaj   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
core   +2 more sources

Pathophysiology of Post-COVID syndromes: a new perspective

Virology Journal, 2022
Key summary points Post-COVID (PCS) syndrome may progress in association with the development of mast cell activation syndrome (MCAS). High D-dimer levels and blood urea nitrogen were observed to be risk factors associated with pulmonary dysfunction in ...
Gaber El-Saber Batiha, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Nermeen N. Welson   +3 more
doaj   +1 more source

The role of heparin in the activation of mast cell tryptase [PDF]

, 2004
Mast cells play an important role in our immune defense against bacteria and parasites but are also key effector cells in various inflammatory diseases. They act by releasing inflammatory mediators from intracellular granules.
Hallgren, Jenny
core   +1 more source

Prognostic factors for the long term outcome after surgical celiac artery decompression in MALS

Orphanet Journal of Rare Diseases, 2023
Background The median arcuate ligament syndrome (MALS) is a rare disease caused by compression of the celiac artery (ORPHA: 293208). Surgical treatment of MALS aims to restore normal celiac blood flow by laparoscopic celiac artery decompression. However,
Anna Woestemeier, Alexander Semaan, Andreas Block, Jan Arensmeyer, Jonas Dohmen, Alexander Kania, Frauke Verrel, Martin Mücke, Jörg C. Kalff, Philipp Lingohr   +9 more
doaj   +1 more source

Continuous diphenhydramine infusion and imatinib for KIT-D816V-negative mast cell activation syndrome: a case report

Journal of Medical Case Reports, 2017
Background We present the first full case report of the treatment of mast cell activation syndrome with continuous diphenhydramine infusion, which resulted in the improvement of anaphylactic reactions and a decrease in hospital readmission.
Faizan Malik, Naveed Ali, Syed Imran Mustafa Jafri, Ali Ghani, Mohsin Hamid, Margot Boigon, Christian Fidler   +6 more
doaj   +1 more source

Insights in Anaphylaxis and Clonal Mast Cell Disorders

Frontiers in Immunology, 2017
The prevalence of anaphylaxis among patients with clonal mast cell disorders (MCD) is clearly higher comparing to the general population. Due to a lower frequency of symptoms outside of acute episodes, clonal MCD in the absence of skin lesions might ...
David González-de-Olano, Iván Álvarez-Twose   +1 more
doaj   +1 more source

Idiopathic osteoporosis, Ehlers–Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder in a 27‐year‐old male patient: A unique case presentation

Clinical Case Reports, 2022
A young male patient presents with widespread pain and varying chronic inflammatory symptoms for three years and idiopathic low bone density for more than ten years.
Cameron Rattray
doaj   +1 more source

Physical Exercise as a Trigger and Therapeutic Tool in Mast Cell Activation Syndrome. A Narrative Literature Review of Mechanisms and Management Strategies

Journal of Education, Health and Sport
Background. Mast Cell Activation Syndrome (MCAS) is characterized by episodic, inappropriate release of mast cell mediators producing multisystem symptoms.
Agnieszka Ewa Kierska, Milena Beata Polak, Julia Płóciennik, Zofia Maria Kania-Bonicka, Gabriela Ewa Łuczyńska   +4 more
doaj   +1 more source