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Mast Cells: A New Frontier for Cancer Immunotherapy
Cells, 2021 Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long been implicated in the pathogenesis of allergic and autoimmune disorders. More recently, mast cells have been recognized as key orchestrators of anti-tumor immunity,
J. Lichterman, S. Reddy
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COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation
The Neuroscientist, 2020 Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated in China. COVID-19 is a global public health emergency of international concern.
D. Kempuraj +10 more
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COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin
Biofactors, 2020 Dear Editor The new coronavirus (severe acute pulmonary syndrome [SARS]-CoV-2) originated in China, where it spread rapidly, and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated ...
T. Theoharides
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Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis
Cells, 2019 The gastrointestinal tract harbours the largest population of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides.
Mercé Albert-Bayo +7 more
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Mast Cells and Their Progenitors in Allergic Asthma
Frontiers in Immunology, 2019 Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
E. Mendez-Enriquez, J. Hallgren
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Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer
International Journal of Molecular Sciences, 2019 Gastric cancer is diagnosed in nearly one million new patients each year and it remains the second leading cause of cancer-related deaths worldwide. Although gastric cancer represents a heterogeneous group of diseases, chronic inflammation has been shown
G. Sammarco +11 more
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Journal of Immunotherapy for Cancer, 2019 BackgroundMast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, the nature, regulation, function, and clinical relevance of mast cells in human gastric cancer (GC) are presently
Yi-pin Lv +18 more
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Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.
JCI Insight, 2018 Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms influencing peripheral motor axon degeneration remain largely unknown.
Emiliano Trias +10 more
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Are Mast Cells MASTers in Cancer?
Frontiers in Immunology, 2017 Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are
G. Varricchi +6 more
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Expression profiling of constitutive mast cells reveals a unique identity within the immune system
Nature Immunology, 2016 Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases.
Daniel F. Dwyer +38 more
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