Results 1 to 10 of about 316,824 (311)
Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis [PDF]
PLoS ONE, 2016 Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant ...
Bai, Yun +10 more
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Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Cambrook, Helen +9 more
core +5 more sources
Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez Shea-Donohue +3 more
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Journal of Innate Immunity, 2021 Mast cells were described and named by Paul Ehrlich in 1879. The observation was based on their unique dye-staining properties. The key roles of mast cells in allergic reactions through IgE-dependent release of histamine are well established [1]. However, mast cells also have a characteristic content of proteases, to which important roles in emerging ...
Arne Egesten, Heiko Herwald
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International Journal of Immunopathology and Pharmacology, 2010 The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. The mast cell inflammatory response is characterized by an early phase with massive discharge of mediators stored in cytoplasmic secretory granules.
Anogeianaki A +19 more
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Mast cell glycosaminoglycans [PDF]
Glycoconjugate Journal, 2016 Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs.
B. Mulloy, R. Lever, C. P. Page
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Mast cell clones: a model for the analysis of cellular maturation. [PDF]
, 1982 Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function.
Cantor, H +10 more
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Future Needs in Mast Cell Biology. [PDF]
, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small ...
de Paulis, Amato +3 more
core +2 more sources
Tetraspanins in Mast Cells [PDF]
Frontiers in Immunology, 2012 Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e.g. by degranulation) is triggered by FcεRI recognition of antigen - IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among
Wolfgang Kempf +4 more
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The mast cell and mast cell disease
Journal of the American Academy of Dermatology, 1995 Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
Jack Longley +2 more
openaire +3 more sources