Results 1 to 10 of about 81,928 (305)

PEDIATRIC MASTOCYTOSIS: AN UPDATE

Mediterranean Journal of Hematology and Infectious Diseases, 2021
Mastocytosis is a rare clonal disorder, characterized by excessive proliferation and accumulation of mast cells (MC) in various organs and tissues. Cutaneous mastocytosis (CM), the most common form in children, is defined when MC infiltration is limited ...
Fiorina Giona
doaj   +6 more sources

Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial

Nature Medicine, 2021
Advanced systemic mastocytosis (AdvSM) is a rare hematologic neoplasm driven by the KIT D816V mutation and associated with poor survival. This phase 1 study (NCT02561988) evaluated avapritinib (BLU-285), a selective KIT D816V inhibitor, in patients with ...
Daniel J Deangelo, Tracy I George, William A Robinson   +2 more
exaly   +2 more sources

Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial

Nature Medicine, 2021
Advanced systemic mastocytosis (AdvSM) is a rare, KIT D816V-driven hematologic neoplasm characterized by mast cell infiltration and shortened survival.
Jason Gotlib, Andreas Reiter, Michael W Deininger   +2 more
exaly   +2 more sources

French guidelines for the management of nonadvanced mastocytosis in adults [PDF]

Orphanet Journal of Rare Diseases
Mastocytosis is a rare disease caused by abnormal mast cell accumulation/proliferation in various organs/tissues. Its clinical features exhibit significant variability irrespective of its clinical presentation, classification, global survival or impact ...
Cristina Bulai Livideanu, Stéphane Barete, Ghandi Damaj, Michel Arock, Julien Rossignol, Olivier Hermine   +5 more
doaj   +2 more sources

Epidemiology of mastocytosis: a population-based study (Sweden)

Acta Oncologica
Background: Mastocytosis is a disease characterized by accumulation of aberrant mast cells and mediator-related symptoms and is divided into systemic mastocytosis (SM) and cutaneous mastocytosis (CM).
Anna Bergström, Hans Hägglund, Anders Berglund, Gunnar Nilsson, Mats Lambe   +4 more
doaj   +2 more sources

Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management

American Journal of Hematology, 2021
Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra‐cutaneous organs.
Animesh D Pardanani
exaly   +2 more sources

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Nature Communications, 2021
Osteoporosis and other manifestations of bone disease are frequent in patients with systemic mastocytosis (SM) in association with the presence of mast cell infiltrates in bone marrow, although the mechanisms behind bone disease remain poorly understood.
Do-Kyun Kim, Geethani Bandara, Young-Eun Cho   +2 more
exaly   +2 more sources

Challenges in the Diagnosis of Cutaneous Mastocytosis

Diagnostics
Background: Mastocytosis is characterized by an accumulation of clonal mast cells (MCs) in tissues such as the skin. Skin lesions in mastocytosis may be clinically subtle or heterogeneous, and giving the correct diagnosis can be difficult.
Knut Brockow, Rebekka Karolin Bent, Simon Schneider, Sophie Spies, Katja Kranen, Benedikt Hindelang, Zsuzsanna Kurgyis, Sigurd Broesby-Olsen, Tilo Biedermann, Clive E. Grattan   +9 more
doaj   +2 more sources

Phenotypic and genotypic characteristics of mastocytosis according to the age of onset. [PDF]

PLoS ONE, 2008
Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease is mostly limited to the skin and often resolves spontaneously.
Fanny Lanternier, Annick Cohen-Akenine, Fabienne Palmerini, Frédéric Feger, Ying Yang, Yael Zermati, Stéphane Barète, Beatrix Sans, Cédric Baude, David Ghez, Felipe Suarez, Richard Delarue, Philippe Casassus, Christine Bodemer, Adeline Catteau, Frédérique Soppelsa, Katia Hanssens, Michel Arock, Hagay Sobol, Sylvie Fraitag, Danièle Canioni, Alain Moussy, Jean Marie Launay, Patrice Dubreuil, Olivier Hermine, Olivier Lortholary, AFIRMM network   +26 more
doaj   +9 more sources

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Blood, 2017
, Cem Akin, Dean D Metcalfe
exaly   +2 more sources