Treatment of Mastocytosis: A Literature Review
Клиническая онкогематология, 2021 The term “mastocytosis” refers to a group of rare heterogeneous disorders resulting from proliferation and accumulation of neoplastic mast cells in various organs.
Karina Maksimovna Chernavina +2 more
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KIT mutation analysis in mast cell neoplasms: recommendations of the European competence network on mastocytosis [PDF]
, 2015 Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in cells and various tissues are poorly defined.
T. Haferlach +74 more
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, 1993 AIMS--To characterise the condition of skeletal mastocytosis, an uncommon cause of apparently "idiopathic" osteoporosis. METHODS--Transiliac crest biopsy specimens submitted over a period of five years were examined for nodular accumulation of mast cells.
Freemont, AJ.; id_orcid, Andrew, S
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Evaluation of Mast Cell Activation Syndromes: Impact of Pathology and Immunohistology [PDF]
, 2012 Mast cell activation syndromes (MCAS) are clinically defined disease states with a largely unknown morphological background. Since mastocytosis may be associated with MCAS, it is crucial in every patient to document or exclude mastocytosis by appropriate
Horny, H. -P., Valent, P., Sotlar, K.
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Cutaneous mastocytosis. a dermatological perspective
, 2021 Mastocytosis is a rare disease characterised by expansion and collection of clonal mast cells in various organs including the skin, bone marrow, spleen, lymph nodes and gastrointestinal tract.
Campione E. +9 more
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Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice
Haematologica, 2016 Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mast cells in the bone marrow and other organ organs/tissues.
Celalettin Ustun +15 more
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Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]
, 2010 Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P. +5 more
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Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]
, 2011 Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Triggiani, Massimo +39 more
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Adult-onset mastocytosis in the skin is highly suggestive of systemic mastocytosis [PDF]
, 2014 Adult-onset urticaria pigmentosa/mastocytosis in the skin almost always persists throughout life. The prevalence of systemic mastocytosis in such patients is not precisely known. Bone marrow biopsies from 59 patients with mastocytosis in the skin and all
Flaig, Michael J. +9 more
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Phenotypic and genotypic characteristics of mastocytosis according to the age of onset. [PDF]
PLoS ONE, 2008 Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease is mostly limited to the skin and often resolves spontaneously.
Fanny Lanternier +26 more
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