Results 31 to 40 of about 6,446 (159)

KIT mutation analysis in mast cell neoplasms: recommendations of the European competence network on mastocytosis [PDF]

, 2015
Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in cells and various tissues are poorly defined.
T. Haferlach, Reiter, A., Sperr, W. R., Akin, C, Valent, P., C. Akin, Garcia-Montero, A., G. Hoermann, Broesby-Olsen, S, Triggiani, M, Escribano, L, Hartmann, K.., Kluin-Nelemans, H. C., Cross, N.C.P., J. Gotlib, A. Reiter, Hermine, O., Akin, C., K. Sotlar, Haferlach, T, S. Broesby Olsen, Hoermann, G., TRIGGIANI, MASSIMO, P. Valent, A. Garcia Montero, Metcalfe, D. D., Sperr, W R, Broesby-Olsen, S., Gotlib, J, Kristensen, T. K., Arock, M, N. C. P. Cross, Schwaab, J., M. Arock, K. Hartmann, Schwaab, J, Metcalfe, D D, Escribano, L., O. Hermine, Kluin-Nelemans, H.C., Hermine, O, W. R. Sperr, J. Schwaab, Hoermann, G, Triggiani, M., Metcalfe, D.D., Cross, N C P, Horny, H.-P., Kluin-Nelemans, H C, Sotlar, K., D. D. Metcalfe, Sperr, W.R., Horny, H-P, Valent, P, Orfao, A., P. Dubreuil, Reiter, A, T. K. Kristensen, Orfao, A, Dubreuil, P., A. Orfao, Gotlib, J., L. Escribano, Sotlar, K, Kristensen, T.K., Hartmann, K., Cross, N. C. P., Haferlach, T., Dubreuil, P, Kielsgaard Kristensen, Thomas, Arock, M., Garcia-Montero, A, H. C. Kluin Nelemans, H. P. Horny, Hartmann, K, Valent, Peter, Orfao, Alberto, García-Montero, Andrés, Arock, Michel, Escribano, Luis   +79 more
core   +1 more source

Evaluation of Mast Cell Activation Syndromes: Impact of Pathology and Immunohistology [PDF]

, 2012
Mast cell activation syndromes (MCAS) are clinically defined disease states with a largely unknown morphological background. Since mastocytosis may be associated with MCAS, it is crucial in every patient to document or exclude mastocytosis by appropriate
Horny, H. -P., Valent, P., Sotlar, K.
core   +1 more source

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

Haematologica, 2016
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mast cells in the bone marrow and other organ organs/tissues.
Celalettin Ustun, Michel Arock, Hanneke C. Kluin-Nelemans, Andreas Reiter, Wolfgang R. Sperr, Tracy George, Hans-Peter Horny, Karin Hartmann, Karl Sotlar, Gandhi Damaj, Olivier Hermine, Srdan Verstovsek, Dean D. Metcalfe, Jason Gotlib, Cem Akin, Peter Valent   +15 more
doaj   +1 more source

Mastocytosis: Fertility and Pregnancy Management in a Rare Disease

Frontiers in Oncology, 2022
Mastocytosis encompasses a subset of rare diseases, characterized by the presence and accumulation of abnormal neoplastic MC in various organ systems, including skin, bone marrow, spleen and gastrointestinal tract.
Jacqueline Ferrari, Pietro Benvenuti, Elisa Bono, Elisa Bono, Nicolas Fiorelli, Chiara Elena   +5 more
doaj   +1 more source

Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]

, 2010
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., H.-P. Horny, Valent, P., P. Valent, Sotlar, K., K. Sotlar   +5 more
core   +1 more source

Mastocytosis in children:A protocol for management

, 2008
Mastocytosis is characterized by an increased number of mast cells with an abnormal growth and accumulation in one or more organs. In most children mastocytosis is limited to the skin (cutaneous mastocytosis) and often transient as compared with that in ...
Pasmans, SGMA, Pasmans, Suzanne G. M. A., Hollander, Jan, Oranje, Arnold, Heide, Rogier, Van Gysel, Dirk, van Gysel, D, De Groot, Hans, Den Hollander, Jan C., Oranje, Arnold P., De Monchy, Jan G. R., Heide, R, de Groot, H, Beishuizen, Auke, Van Doormaal, Jasper J., van Doormaal, JJ, de Monchy, JGR, Dutch National Mastocytosis Work Group   +17 more
core   +2 more sources

Phenotypic and genotypic characteristics of mastocytosis according to the age of onset. [PDF]

PLoS ONE, 2008
Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease is mostly limited to the skin and often resolves spontaneously.
Fanny Lanternier, Annick Cohen-Akenine, Fabienne Palmerini, Frédéric Feger, Ying Yang, Yael Zermati, Stéphane Barète, Beatrix Sans, Cédric Baude, David Ghez, Felipe Suarez, Richard Delarue, Philippe Casassus, Christine Bodemer, Adeline Catteau, Frédérique Soppelsa, Katia Hanssens, Michel Arock, Hagay Sobol, Sylvie Fraitag, Danièle Canioni, Alain Moussy, Jean Marie Launay, Patrice Dubreuil, Olivier Hermine, Olivier Lortholary, AFIRMM network   +26 more
doaj   +1 more source

Splenic Mastocytosis [PDF]

Blood, 1958
Abstract 1. A patient with splenic mastocytosis who had hypersplenism, periodic flushing and clotting defects is presented. 2. A correlation is shown between mastocytosis and elevated histamine and heparin levels in the spleen. 3. The patient is well nine months after splenectomy. 4.
N, ENDE, E I, CHERNISS
openaire   +2 more sources

Successful treatment with Omalizumab of a child affected by Systemic Mastocytosis: clinical and biological implications

Italian Journal of Pediatrics, 2023
Background Pediatric Mastocytosis is a rare and heterogeneous disease, characterized by accumulation of mast cells in the skin (Cutaneous Mastocytosis) and/or, less frequently, in other organs, mainly liver, spleen, bone marrow, lymph nodes and ...
Grazia Bossi, Valeria Brazzelli, Mara De Amici, Daniela Pietra, Chiara Raviola, Matteo Naso, Corrado Regalbuto, Federica Boselli, Valeria Fortina, Gian Luigi Marseglia   +9 more
doaj   +1 more source

Diagnostic Evaluation of Hypersensitivity Reactions to Antibiotics in a Large Cohort of Mastocytosis Patients

Diagnostics, 2023
Background: Anaphylactic reactions are a well-known feature of mastocytosis, particularly in relation to hymenoptera venom stings. Although data on the frequency of drug hypersensitivity reactions is limited in mastocytosis, it is hypothesized that these
Jesper Jarkvist, Theo Gülen
doaj   +1 more source