Results 11 to 20 of about 81,928 (305)
Current Opinion in Allergy and Clinical Immunology, 2001 It is known that patients with mastocytosis have an increased risk of anaphylaxis. This also appears to be the case with patients with evidence of a clonal mast cell disorder resulting in the monoclonal mast cell activation syndrome (MMAS) who do not express the full mastocytosis phenotype.
K, Brockow, D D, Metcalfe
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Next Generation Sequencing of Genes With Epigenetic Alterations in Mastocytosis. [PDF]
Clin Transl AllergyABSTRACT Aim Mastocytosis is a neoplastic disease of the bone marrow associated with the risk of frequent and severe allergic reactions. However, the genetic predisposition is not fully understood, and the crucial element in pathogenesis is the presence of the oncogenic KIT p. D816 V gene mutation.
Górska A +5 more
europepmc +2 more sources
Blood, 1958 Abstract 1. A patient with splenic mastocytosis who had hypersplenism, periodic flushing and clotting defects is presented. 2. A correlation is shown between mastocytosis and elevated histamine and heparin levels in the spleen. 3. The patient is well nine months after splenectomy. 4.
Norman Ende, EDWARD I. CHERNISS
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Journal of Investigative Dermatology, 1991 The most frequent site of organ involvement in patients with any form of mastocytosis is the skin. Cutaneous expressions include urticaria pigmentosa, mastocytoma, diffuse and erythrodermic cutaneous mastocytosis, and telangiectasia macularis eruptiva perstans. The cutaneous lesions tend to appear early in life.
Nicholas A. Soter
openalex +4 more sources
Systemic mastocytosis in adults: 2023 update on diagnosis, risk stratification and management
American journal of hematology/oncology, 2023 Systemic mastocytosis (SM) results from clonal proliferation of mast cells (MC) in extracutaneous organs.
A. Pardanani
semanticscholar +1 more source
Zdorovʹe Rebenka, 2022 Background. Mastocytosis is a disease characterized by the presence of mast cells in various organs. The skin is affected most often. Almost every patient diagnosed with mastocytosis has skin lesions.
O.L. Statkevych, T.V. Sviatenko
doaj +1 more source
Indian Journal of Dermatology, 2007 Mastocytosis is a condition characterized by the disorderly infiltration of mast cells in several tissues and comprises many different clinical situations varying from indolent cutaneous forms to malignant and systemic conditions. Bullous mastocytosis is
Nayak Surajit +3 more
doaj +2 more sources
Avapritinib versus Placebo in Indolent Systemic Mastocytosis.
NEJM Evidence, 2023 Avapritinib in Indolent Systemic MastocytosisIn a randomized trial, patients with indolent systemic mastocytosis were treated with avapritinib or placebo along with supportive care.
J. Gotlib +52 more
semanticscholar +1 more source
Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients
Orphanet Journal of Rare Diseases, 2021 Background Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ systems.
Fatma Jendoubi +5 more
doaj +1 more source
Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis [PDF]
, 2016 Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant ...
Bai, Yun +10 more
core +12 more sources