Results 51 to 60 of about 81,928 (305)
Review papers The role of KIT gene mutations in pathogenesis of pediatric mastocytosis
Przegląd Dermatologiczny, 2015 Mastocytosis is characterized by excessive proliferation and accumulation of mast cells in skin and/or other organs. Two forms of the disease, cutaneous and systemic mastocytosis, differ significantly in symptomatology and clinical course.
Joanna Dawicka +5 more
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Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]
, 2010 Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., Sotlar, K., Valent, P.
core +1 more source
Mastocytosis – an update [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2010 SummaryMastocytosis (MC) encompasses a range of disorders characterized by a clonal, pathological accumulation of mast cells having a somatic activating mutation of the tyrosine kinase receptor Kit (exon 17, codon 816; D816V) in more than 90 % of adult patients. The mutation is much less common in children. Skin and bone marrow are most often affected.
Amon, Ulrich +3 more
openaire +3 more sources
Italian Journal of Pediatrics, 2023 Background Pediatric Mastocytosis is a rare and heterogeneous disease, characterized by accumulation of mast cells in the skin (Cutaneous Mastocytosis) and/or, less frequently, in other organs, mainly liver, spleen, bone marrow, lymph nodes and ...
Grazia Bossi +9 more
doaj +1 more source
Diagnostics, 2023 Background: Anaphylactic reactions are a well-known feature of mastocytosis, particularly in relation to hymenoptera venom stings. Although data on the frequency of drug hypersensitivity reactions is limited in mastocytosis, it is hypothesized that these
Jesper Jarkvist, Theo Gülen
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Clinical effectiveness of hymenoptera venom immunotherapy [PDF]
, 2013 Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during ...
Aberer, Werner +21 more
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Mastocytosis and Mast Cell Activation Disorders: Clearing the Air
International Journal of Molecular Sciences, 2021 Mast cells are derived from hematopoietic stem cell precursors and are essential to the genesis and manifestations of the allergic response. Activation of these cells by allergens leads to degranulation and elaboration of inflammatory mediators ...
Clayton Jackson +4 more
semanticscholar +1 more source
A unique presentation of pulmonary disease in advanced systemic mastocytosis, proven by the presence of mast cells in bronchoalveolar lavage: A case report [PDF]
, 2016 Background: Systemic mastocytosis is a rare myeloproliferative disease characterized by the uncontrolled proliferation of aberrant mast cells. It has varying clinical manifestations.
Broijl, A. (Annemiek) +2 more
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Gastrointestinal Manifestations in Systemic Mastocytosis: The Need of a Multidisciplinary Approach
Cancers, 2021 Simple Summary Mastocytosis is a group of neoplastic mast cell disorders ranging from a skin-limited disease to a systemic form with multi-organ involvement, including gut involvement.
M. Zanelli +18 more
semanticscholar +1 more source
Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis [PDF]
, 2013 Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a ...
Aladzsity István +14 more
core +1 more source