Results 61 to 70 of about 81,928 (305)

Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.

Blood, 2020
Mastocytosis is a hematopoietic neoplasm characterized by expansion of KIT D816V-mutated clonal mast cells in various organs and severe or even life-threatening anaphylactic reactions.
Georg Greiner, Bettina Sprinzl, A. Górska, F. Ratzinger, Michael Gurbisz, Nadine Witzeneder, K. Schmetterer, B. Gisslinger, G. Uyanik, E. Hadzijusufovic, H. Esterbauer, K. Gleixner, M. Krauth, M. Pfeilstöcker, F. Keil, H. Gisslinger, B. Nedoszytko, M. Niedoszytko, W. Sperr, P. Valent, G. Hoermann   +20 more
semanticscholar   +1 more source

A Multidisciplinary Diagnostic Approach Reveals a Higher Prevalence of Indolent Systemic Mastocytosis: 15-Years’ Experience of the GISM Network

Cancers, 2021
Simple Summary The approach of the Interdisciplinary Group for Study of Mastocytosis (GISM) of Verona, based on a regional network of clinical specialists and expert pathologists, with the availability of sensitive molecular and flow-cytometry diagnostic
R. Zanotti, M. Bonifacio, Cecilia Isolan, I. Tanasi, L. Crosera, Francesco Olivieri, G. Orsolini, D. Schena, P. Bonadonna   +8 more
semanticscholar   +1 more source

PD-1 Regulates the Growth of Human Mastocytosis Cells

Allergology International, 2013
Background: Programmed death-1 (PD-1) is a marker for human neoplastic T cells. Here, we evaluated whether or not PD-1 was also a marker for human mastocytosis, and explored the role of PD-1 in human mastocytosis cells.
Tatsuki R. Kataoka, Masakazu Fujimoto, Koki Moriyoshi, Itsuko Koyanagi, Chiyuki Ueshima, Fumihiko Kono, Tatsuaki Tsuruyama, Yoshimichi Okayama, Chisei Ra, Hironori Haga   +9 more
doaj   +1 more source

A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]

, 2013
The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen, Geldhof, Peter, Masure, Dries, Van Den Broeck, Wim, Vercruysse, Jozef, Vlaminck, Johnny, Wang, Tao   +6 more
core   +4 more sources

New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis.

Blood, 2020
Systemic mastocytosis (SM) has greatly benefited from the broad application of precision medicine techniques to hematolymphoid neoplasms. Sensitive detection of the recurrent KIT D816V mutation and use of next generation sequencing (NGS) panels to ...
A. Reiter, T. George, J. Gotlib
semanticscholar   +1 more source

Mediator-Related Symptoms and Anaphylaxis in Children with Mastocytosis

International Journal of Molecular Sciences, 2021
Mastocytosis is characterized by the pathological accumulation of mast cells (MC) in various organs. In these patients, MC may degranulate and thereby contribute to clinical symptoms, especially when a concomitant allergy is present.
K. Brockow, K. Plata-Nazar, M. Lange, B. Nedoszytko, M. Niedoszytko, P. Valent   +5 more
semanticscholar   +1 more source

Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder [PDF]

, 2015
Although more than 90% systemic mastocytosis (SM) patients express gain of function mutations in the KIT receptor, recent next generation sequencing has revealed the presence of several additional genetic and epigenetic mutations in a subset of these ...
Chatterjee, Anindya, Ghosh, Joydeep, Kapur, Reuben   +2 more
core   +2 more sources

Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis

Theranostics, 2021
In systemic mastocytosis (SM), the clinical features and survival vary greatly. Patient-related factors determining the outcome in SM are largely unknown.
H. Kluin-Nelemans, M. Jawhar, A. Reiter, B. Anrooij, J. Gotlib, Karin, Hartmann, A. Illerhaus, H. Elberink, A. Górska, M. Niedoszytko, M. Lange, L. Scaffidi, R. Zanotti, P. Bonadonna, C. Perkins, C. Elena, Luca, Malcovati, Khalid Shoumariyeh, N. Bubnoff, S. Müller, M. Triggiani, Roberta, Parente, J. Schwaab, M. Kundi, A. B. Fortina, F. Caroppo, K. Brockow, A. Zink, D. Fuchs, I. Angelova-Fischer, A. Yavuz, M. Doubek, Mattias, Mattsson, H. Hagglund, J. Panse, Anne Simonowski, V. Sabato, T. Schug, M. Jentzsch, C. Breynaert, J. Várkonyi, Vanessa E. Kennedy, O. Hermine, J. Rossignol, Michel, Arock, P. Valent, W. Sperr   +51 more
semanticscholar   +1 more source

Pseudoxanthomatous mastocytosis [PDF]

International Journal of Dermatology, 2007
A 50‐year‐old woman presented with itchy, multiple, flat, yellowish, waxy papules and plaques diffusely involving her face, trunk, and upper extremities for 5 years (Fig. 1). Itching was moderate to severe in intensity and was episodic, without any identifiable aggravating or relieving factors.
Neeraj Srivastava, Satish Chand, Sanjay Singh   +2 more
openalex   +4 more sources

Mast Cell Sarcoma of the Retroperitoneum With Concurrent Systemic Mastocytosis and an Undisclosed Associated Hematologic Neoplasm: A Case Report

Clinical Pathology, 2022
Mastocytosis is a rare disorder affecting both children and adults by gathering of functionally defective mast cells in the body’s tissues. The World Health Organization (WHO) classified mastocytosis into cutaneous mastocytosis, systemic mastocytosis (SM)
Ing Chen, Jia-Bin Liao, Jung-Chia Lin, Pin-Pen Hsieh, Ming-Yun Hsieh   +4 more
doaj   +1 more source