Results 1 to 10 of about 162 (128)

In Vitro and In Vivo Inhibition of MATE1 by Tyrosine Kinase Inhibitors [PDF]

Pharmaceutics, 2021
The membrane transport of many cationic prescription drugs depends on facilitated transport by organic cation transporters of which several members, including OCT2 (SLC22A2), are sensitive to inhibition by select tyrosine kinase inhibitors (TKIs).
Muhammad Erfan Uddin, Zahra Talebi, Sijie Chen, Yan Jin, Alice A. Gibson, Anne M. Noonan, Xiaolin Cheng, Shuiying Hu, Alex Sparreboom   +8 more
doaj   +3 more sources

In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs [PDF]

International Journal of Molecular Sciences, 2021
The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT3 antagonist drug used to prevent nausea and vomiting, can inhibit OCT2- and MATE1-mediated transport. The purpose of this study was to test the ability of five 5-HT3 antagonist
Xia Wen, Edgar A Jaimes, Lauren M Aleksunes   +2 more
exaly   +3 more sources

Double‐transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations [PDF]

British Journal of Pharmacology, 2011
BACKGROUND AND PURPOSE The organic cation transporters 1 (OCT1) and 2 (OCT2) mediate drug uptake into hepatocytes and renal proximal tubular cells, respectively. Multidrug and toxin extrusion protein 1 (MATE1) is a major component of subsequent export into bile and urine.
Jörg KÖNIG, Oliver Zolk, Carsten Hoffmann   +2 more
exaly   +3 more sources

Structural basis of drug recognition by human MATE1 transporter

Nature Communications
Human MATE1 (multidrug and toxin extrusion protein 1) is highly expressed in the kidney and liver, where it mediates the final step in the excretion of a broad range of cationic drugs, including the antidiabetic drug metformin, into the urine and bile ...
Ksenija Romane, Giulia Peteani, Somnath Mukherjee, Julia Kowal, Lorenzo Rossi, Jingkai Hou, Anthony A. Kossiakoff, Thomas Lemmin, Kaspar P. Locher   +8 more
doaj   +4 more sources

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity [PDF]

Biochemical Pharmacology, 2010
Multidrug and toxin extrusion 1 (MATE1/SLC47A1) is expressed in the brush-border membrane of renal proximal tubules and mediates the efflux of cationic drugs. In the present study, the role of MATE1 in the nephrotoxicity of cisplatin was investigated in vivo and in vitro.
Takanori Nakamura, Atsushi Yonezawa, Toshiya Katsura   +2 more
exaly   +3 more sources

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia

International Journal of Molecular Sciences, 2022
Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ventricular cardiac arrhythmias.
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom   +25 more
openaire   +2 more sources

Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function

Biomedicines, 2023
Metformin plasma exposure is increased in rats with thioacetamide (TAA)-induced liver failure. The absorption, distribution, and excretion process of metformin is mainly mediated by organic cation transporters (OCTs) and multidrug and toxin extrusion ...
Hao Zhi, Yidong Dai, Lin Su, Lu Yang, Wenhan Wu, Zehua Wang, Xinyue Zhu, Li Liu, Jiye Aa, Hanyu Yang   +9 more
doaj   +1 more source

OCT2 and MATE1 Provide Bidirectional Agmatine Transport [PDF]

Molecular Pharmaceutics, 2010
Agmatine is a biogenic amine (l-arginine metabolite) of potential relevance to several central nervous system (CNS) conditions. The identities of transporters underlying agmatine and polyamine disposition in mammalian systems are not well-defined.
Tate N, Winter, William F, Elmquist, Carolyn A, Fairbanks   +2 more
openaire   +2 more sources

Evaluation of drug–drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling

CPT: Pharmacometrics & Systems Pharmacology, 2022
Pemigatinib is a potent inhibitor of fibroblast growth factor receptor being developed for oncology indications. It is primarily metabolized by cytochrome P450 (CYP) 3A4, and the ratio of estimated concentration over concentration required for 50 ...
Tao Ji, Xuejun Chen, Swamy Yeleswaram
doaj   +1 more source

The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics

Molecules, 2022
With the widespread clinical use of drug combinations, the incidence of drug–drug interactions (DDI) has significantly increased, accompanied by a variety of adverse reactions.
Birui Shi, Yan Zhang, Baolin Huang, Huiping Lin, Qiong Zhou, Yujue Wang, Zheng Cai, Menghua Liu   +7 more
doaj   +1 more source