Results 21 to 30 of about 2,631 (192)

Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2 [PDF]

J Med Chem
The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Redeker, Kyra-Elisa Maria, Tzvetkov, Mladen, Boretius, Susann, Brockmöller, Jürgen, Kirsch, Nicolai   +4 more
core   +2 more sources

The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin [PDF]

Clinical Pharmacology & Therapeutics, 2012
Interindividual variation in response to metformin, first-line therapy for type 2 diabetes, is substantial. Given that transporters are determinants of metformin pharmacokinetics, we examined the effects of promoter variants in both multidrug and toxin extrusion protein 1 (MATE1) (g.-66T → C, rs2252281) and MATE2 (g.-130G → A, rs12943590) on variation ...
Stocker, SL, Morrissey, KM, Yee, SW, Castro, RA, Xu, L, Dahlin, A, Ramirez, AH, Roden, DM, Wilke, RA, McCarty, CA, Davis, RL, Brett, CM, Giacomini, KM   +12 more
openaire   +5 more sources

The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study [PDF]

Clinical Pharmacokinetics
Trifluridine/tipiracil, registered for the treatment of patients with metastatic gastric and colorectal cancer, is a substrate and inhibitor for the organic cation transporter 2 (OCT2) and the multidrug and toxin extrusion protein 1 (MATE1), which raises the potential for drug-drug interactions with other OCT2/MATE1 modulators.
Niels A. D. Guchelaar, Stefan A. J. Buck, Leni van Doorn, Koen G. A. M. Hussaarts, Yorick Sandberg, Annemieke van der Padt-Pruijsten, Robbert J. van Alphen, Laura Poppe-Manenschijn, Isolde Vleut, Peter de Bruijn, Roelof W. F. van Leeuwen, Bianca Mostert, Ferry A. L. M. Eskens, Esther Oomen-de Hoop, Stijn L. W. Koolen, Ron H. J. Mathijssen   +15 more
openaire   +4 more sources

Analysis of Genetic Polymorphisms of OCT1, MATE1, MATE2 and GLP1R in Rats with Experimentally Induced Obesity

Acta Medica Bulgarica
The experimental model of obesity based on a cafeteria diet is a common model to investigate different aspects of obesity. The present study aimed to evaluate the link between genetic variants of OCT1, MATE1, MATE2 and GLP1R and the treatment effects in ...
Kalinkova M., Kadiyska T., Dabchev K., Bogdanov G., Handjieva-Darlenska T.   +4 more
doaj   +2 more sources

Characterization, genetic diversity, phylogenetic relationships, and expression of the aluminum tolerance MATE1 gene in Secale species

Biologia Plantarum, 2018
Aluminum (Al) is the main limiting factor for crop production in acidic soils. Efflux of organic acids is one of the mechanisms that determine Al-tolerance, and an Al-activated citrate transporter (multidrug and toxic compound extrusion) MATE1 gene is ...
E. Santos, C. Benito, J. Silva-Navas, F. J. Gallego, A. M. Figueiras, O. Pinto-Carnide, M. Matos   +6 more
doaj   +2 more sources

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability [PDF]

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects. Existing predictors are substrate‐agnostic and cannot capture how a single amino acid change differentially affects transport across
Yoomi Park, Yitian Zhou, Ming Xiao, Anne T. Nies, Volker M. Lauschke   +4 more
wiley   +2 more sources

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes [PDF]

Frontiers in Pharmacology
BackgroundMetformin is the first-line antidiabetic therapy for type 2 diabetes in Mexico, despite recent recommendations highlighting alternatives like GLP-1 receptor agonists for individuals with obesity.
Oscar I. Chávez-Arreola, Brissia Lazalde, Marisol López-López, Alberto Ortega-Vázquez, Alberto Ortega-Vázquez, Quitzia L. Torres-Salazar   +5 more
doaj   +2 more sources

Platinum–Acridine Agents with High Activity in Cancers Expressing the Solute Carrier MATE1 (SLC47A1)

, 2023
Platinum–acridine anticancer agents (PAs) containing acyclic (1 and 3) and heterocyclic (R)-3-aminopiperidine (2) and 2-iminopyrrolidine (4) based linker moieties were studied.
Shenjie, Zhang, Haoqing, Wu, Cynthia, Day, Ulrich, Bierbach   +3 more
core   +1 more source

Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

Scientific Reports, 2021
Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds ...
Csilla Ambrus, Éva Bakos, Balázs Sarkadi, Csilla Özvegy-Laczka, Ágnes Telbisz   +4 more
doaj   +1 more source

MATE1 topology: accessibility of native cysteine residues in MATE1 to an impermeant thiol‐reactive reagent

The FASEB Journal, 2008
Mammalian multidrug and toxic compound extrusion(MATE) proteins have been suggested to mediate polyspecific H + ‐coupled transport of organic cations(OCs) in the apical membrane of proximal tubules.
Xiaohong Zhang, Stephen Wright
openaire   +1 more source