Results 11 to 20 of about 2,631 (192)

Bupropion decreases plasma levels of asymmetric dimethylarginine and ameliorates renal injury by modulation of Ddah1, Oatp4c1, Oct2, and Mate1 in rats with adenine-induced chronic renal injury [PDF]

Frontiers in Pharmacology
ObjectiveThe objective of the study was to investigate whether bupropion (BUP) or its circulation metabolites could decrease plasma level of asymmetric dimethylarginine (ADMA) and ameliorate renal injury by modulation of Ddah1, Oatp4c1, Oct2, and Mate1 ...
Lulu Huang, Lulu Huang, Lulu Huang, Yun Xiao, Yun Xiao, Yun Xiao, Xiaoyu Han, Xiaoyu Han, Xiaoyu Han, Yang Yu, Chao Zheng, Chao Zheng, Chao Zheng, Xiangdong Fang, Qing Li, Fanglan Liu, Fanglan Liu, Chunhua Xia, Chunhua Xia, Yongjie Zhang, Jiake He, Jiake He, Jiake He   +22 more
doaj   +3 more sources

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)

Scientific Reports, 2018
Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells.
A. Gessner, J. König, M. F. Fromm
doaj   +2 more sources

Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1 [PDF]

Scientific Reports, 2018
AbstractCreatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1). We previously showed that the tyrosine kinase inhibitor (TKI) crizotinib inhibits OCT2-mediated transport of creatinine.
Saki Omote, Natsumi Matsuoka, Hiroshi Arakawa, Takeo Nakanishi, Ikumi Tamai   +4 more
openaire   +3 more sources

Aluminum tolerance in maize is associated with higher MATE1 gene copy number [PDF]

Proceedings of the National Academy of Sciences, 2013
Genome structure variation, including copy number variation and presence/absence variation, comprises a large extent of maize genetic diversity; however, its effect on phenotypes remains largely unexplored. Here, we describe how copy number variation underlies a rare allele that contributes to maize aluminum (Al) tolerance.
Maron, Lyza G., Guimarães, Claudia T., Kirst, Matias, Albert, Patrice S., Birchler, James A., Bradbury, Peter J., Buckler, Edward S., Coluccio, Alison E., Danilova, Tatiana V., Kudrna, David, Magalhaes, Jurandir V., Piñeros, Miguel A., Schatz, Michael C., Wing, Rod A., Kochian, Leon V.   +14 more
openaire   +7 more sources

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin [PDF]

Clinical Pharmacokinetics, 2015
Pharmacokinetic outcomes of transporter-mediated drug-drug interactions (TMDDIs) are increasingly being evaluated clinically. The goal of our study was to determine the effects of selective inhibition of multidrug and toxin extrusion protein 1 (MATE1), using famotidine, on the pharmacokinetics and pharmacodynamics of metformin in healthy volunteers ...
Hibma, Jennifer E, Zur, Arik A, Castro, Richard A, Wittwer, Matthias B, Keizer, Ron J, Yee, Sook Wah, Goswami, Srijib, Stocker, Sophie L, Zhang, Xuexiang, Huang, Yong, Brett, Claire M, Savic, Radojka M, Giacomini, Kathleen M   +12 more
openaire   +5 more sources

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS ONE, 2019
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai   +5 more
doaj   +2 more sources

Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1 [PDF]

Pharmacogenetics and Genomics, 2009
Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs. In this study, we characterized the transcriptional effects of five polymorphic variants and six common haplotypes in the basal promoter region of MATE1 ...
Choi, JH Choi, Ji Ha, Yee, SW Yee, Sook Wah, Kim, MJ Kim, Mee J., Nguyen, L Nguyen, Loan, Lee, JH Lee, Jeong Ho, Kang, JO Kang, Ji-One, Hesselson, S Hesselson, Stephanie, Castro, RA Castro, Richard A., Stryke, D Stryke, Doug, Johns, SJ Johns, Susan J., Kwok, PY Kwok, Pui-Yan, Ferrin, TE Ferrin, Thomas E., Lee, MG Lee, Min Goo, Black, BL Black, Brain L., Ahituv, N Ahituv, Nadav, Giacomini, KM Giacomini, Kathleen M.   +15 more
openaire   +5 more sources

Prediction of Inhibitory Activity Against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models [PDF]

J Chem Inf Model
Renal secretion plays an important role in drug excretion from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2-K and OCT2, the former of which is highly related to drug-drug interactions.
Andreas, Bender, Satoshi, Asano, Koichi, Handa, Takeshi, Iijima, Michiharu, Kageyama, Shunta, Sasaki   +5 more
core   +5 more sources

Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

Respiratory Research, 2018
Background Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and OCTN2 were investigated in human ...
Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord, Lena Gustavsson   +10 more
doaj   +2 more sources

Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins [PDF]

Amino Acids
The L-arginine derivative and uremic toxin symmetric dimethylarginine (SDMA) is an independent risk marker for total mortality and cardiovascular events.
Lorenz A. Scherpinski, Martin F. Fromm, Renke Maas, Jörg König   +3 more
doaj   +2 more sources