Results 31 to 40 of about 2,631 (192)

Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells

Journal of Pharmacological Sciences, 2016
This study aimed to determine the effect of multidrug and toxin extrusion protein 1 (MATE1) genetic variants on its transcript expression in peripheral blood cells.
Hitoshi Ando, Kazuhiko Nakano, Kentaro Ushijima, Shinsuke Kurokawa, Satoshi Washino, Keiko Hosohata, Tatsuo Morita, Akio Fujimura   +7 more
doaj   +1 more source

Analysis of missense SNPs in the SLC47A1 and SLC47A2 genes affecting the pharmacokinetics of metformin: Computational approach

Egyptian Journal of Medical Human Genetics, 2022
Background Metformin as an anti-hyperglycaemic drug is commonly used for the treatment of type 2 diabetes mellitus (T2DM). The metformin response is variable due to the interindividual variation of pharmacokinetics which is based on strong genetic ...
Orcun Avsar
doaj   +1 more source

Substrate-Dependent Inhibition of Human MATE1 by Cationic Ionic Liquids [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2013
The multidrug and toxin extruders 1- and 2-K (MATE1 and MATE2-K) are expressed in the luminal membrane of renal proximal tubule cells and provide the active step in the secretion of molecules that carry a net positive charge at physiologic pH, so-called organic cations.
Lucy J, Martínez-Guerrero, Stephen H, Wright   +1 more
openaire   +2 more sources

Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride [PDF]

British Journal of Pharmacology, 2016
Background and PurposeNitidine chloride (NC), a benzophenanthridine alkaloid, has various biological properties including anticancer and analgesic activities. The aim of the present study was to evaluate the role of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1) in the renal disposition and nephrotoxicity of NC ...
L P, Li, F F, Song, Y Y, Weng, X, Yang, K, Wang, H M, Lei, J, Ma, H, Zhou, H D, Jiang   +8 more
openaire   +2 more sources

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

, 2016
The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug–drug interactions (DDIs) and alterations in drug exposure and accumulation ...
Arik A. Zur (1992202), Kathleen M. Giacomini (259990), Yasuto Kido (1648075), Matthias B. Wittwer (1992199), Kari M. Morrissey (638647), Natalia Khuri (1992196), Xuexiang Zhang (1992205), Andrej Sali (17326), Alan Kosaka (1367), Yong Huang (15745)   +9 more
core   +3 more sources

MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients [PDF]

Blood Cancer Journal, 2016
AbstractAlthough imatinib is highly effective in the treatment of chronic myeloid leukemia (CML), 25–30% patients do not respond or relapse after initial response. Imatinib uptake into targeted cells is crucial for its molecular response and clinical effectiveness.
Harrach, S, Schmidt-Lauber, C, Pap, T, Pavenstädt, H, Schlatter, E, Schmidt, E, Berdel, W E, Schulze, U, Edemir, B, Jeromin, S, Haferlach, T, Ciarimboli, G, Bertrand, J   +12 more
openaire   +2 more sources

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Malaria Journal, 2017
Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink   +7 more
doaj   +1 more source

Characterization of SLC transporters in human skin

ADMET and DMPK, 2015
Most identified drug transporters belong to the ATP-binding Cassette (ABC) and Solute Carrier (SLC) families. Recent research indicates that some of these transporters play an important role in the absorption, distribution and excretion of drugs, and are
Marion Alriquet, Karine Sevin, Alexandre Gaborit, Pierre Comby, Bernard Ruty, Hanan Osman-Ponchet   +5 more
doaj   +1 more source

The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response.

PLoS ONE, 2022
Interindividual variation is important in the response to metformin as the first-line therapy for type-2 diabetes mellitus (T2DM). Considering that OCT1 and MATE1 transporters determine the metformin pharmacokinetics, this study aimed to investigate the ...
Vitarani Dwi Ananda Ningrum, Ahmad Hamim Sadewa, Zullies Ikawati, Rika Yuliwulandari, M Robikhul Ikhsan, Rohmatul Fajriyah   +5 more
doaj   +1 more source

Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models

Frontiers in Pharmacology, 2021
Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g.
Bastian Haberkorn, Martin F. Fromm, Jörg König   +2 more
doaj   +1 more source