The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice [PDF]
Neonatal maternal separation is a widely used method to construct an early-life stress model in rodents. In this method, pups are separated from their mothers for several hours every day during the first 2 weeks of life, which results in adverse early ...
Sangyep Shin, Sukwon Lee
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Effects of BDNF Signaling on Anxiety-Related Behavior and Spatial Memory of Adolescent Rats in Different Length of Maternal Separation [PDF]
As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the development of cognition and behaviors of adolescent rodents.
Xianqiang Zhang+11 more
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Maternal separation has been shown to disrupt proper brain development and maturation, having profound consequences on the neuroendocrine systems in charge of the stress response, and has been shown to induce behavioral and cognitive abnormalities.
Sara Mejía-Chávez+4 more
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Maternal separation in rats induces neurobiological and behavioral changes on the maternal side [PDF]
AbstractThe time after parturition is a sensitive period for mothers where they are prone to develop psychopathological symptoms. Studies investigating dams after separation from their pups (maternal separation, MS) showed that MS induces alterations similar to postpartum depression.
Bölükbas, Ibrahim+2 more
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Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents [PDF]
The mechanisms by which childhood maltreatment increases anxiety is unclear, but a propensity for increased defensive behavior in rodent models of early life stress (ELS) suggests that work in rodents may clarify important mechanistic details about this ...
Daniel Wang+4 more
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Dissociative symptoms in school-aged adopted children who experienced maternal separation and disruptive caregiving in infancy [PDF]
Amounting findings on maternal separation and early disturbed caregiving suggest that this type of early experience negatively influences socioemotional development and may be associated with behavioral and mental health problems in later life ...
Petra Winnette+3 more
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More than 300 million people suffer from depressive disorders globally. People under early-life stress (ELS) are reportedly vulnerable to depression in their adulthood, and synaptic plasticity can be the molecular mechanism underlying such depression ...
Yongfei Cui+11 more
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Effects of Early-Life Stress on the Brain and Behaviors: Implications of Early Maternal Separation in Rodents [PDF]
Early-life stress during the prenatal and postnatal periods affects the formation of neural networks that influence brain function throughout life. Previous studies have indicated that maternal separation (MS), a typical rodent model equivalent to early ...
Mayumi Nishi
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Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation. [PDF]
Background Intestinal microbial composition not only affects the health of the gut but also influences centrally mediated systems involved in mood, through the “gut-brain” axis, a bidirectional communication between gut microbiota and the brain.
De Santa F+8 more
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Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice. [PDF]
Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still developing.
Irene Gracia-Rubio+5 more
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