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The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice [PDF]

Frontiers in Molecular Neuroscience, 2023
Neonatal maternal separation is a widely used method to construct an early-life stress model in rodents. In this method, pups are separated from their mothers for several hours every day during the first 2 weeks of life, which results in adverse early ...
Sangyep Shin, Sukwon Lee
doaj   +3 more sources

Effects of BDNF Signaling on Anxiety-Related Behavior and Spatial Memory of Adolescent Rats in Different Length of Maternal Separation [PDF]

Frontiers in Psychiatry, 2020
As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the development of cognition and behaviors of adolescent rodents.
Xianqiang Zhang, Haonan Li, Haoran Sun, Yinghong Jiang, Aihong Wang, Yujia Kong, Xiue Sun, Guohui Zhu, Qi Li, Zhongde Du, Hongwei Sun, Lin Sun   +11 more
doaj   +3 more sources

Maternal Separation Modifies the Activity of Social Processing Brain Nuclei Upon Social Novelty Exposure

Frontiers in Behavioral Neuroscience, 2021
Maternal separation has been shown to disrupt proper brain development and maturation, having profound consequences on the neuroendocrine systems in charge of the stress response, and has been shown to induce behavioral and cognitive abnormalities.
Sara Mejía-Chávez, Arturo Venebra-Muñoz, Fabio García-García, Aleph Alejandro Corona-Morales, Arturo Enrique Orozco-Vargas   +4 more
doaj   +2 more sources

Maternal separation in rats induces neurobiological and behavioral changes on the maternal side [PDF]

Scientific Reports, 2020
AbstractThe time after parturition is a sensitive period for mothers where they are prone to develop psychopathological symptoms. Studies investigating dams after separation from their pups (maternal separation, MS) showed that MS induces alterations similar to postpartum depression.
Bölükbas, Ibrahim, Mundorf, Annakarina (Dr. rer. nat.), Freund, Nadja (Jun.-Prof. Dr.)   +2 more
openaire   +6 more sources

Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents [PDF]

Translational Psychiatry, 2020
The mechanisms by which childhood maltreatment increases anxiety is unclear, but a propensity for increased defensive behavior in rodent models of early life stress (ELS) suggests that work in rodents may clarify important mechanistic details about this ...
Daniel Wang, Jessica L.S. Levine, Victor J. Avila‐Quintero, Michael H. Bloch, Arie Kaffman   +4 more
openalex   +2 more sources

Dissociative symptoms in school-aged adopted children who experienced maternal separation and disruptive caregiving in infancy [PDF]

Frontiers in Psychiatry
Amounting findings on maternal separation and early disturbed caregiving suggest that this type of early experience negatively influences socioemotional development and may be associated with behavioral and mental health problems in later life ...
Petra Winnette, Petra Winnette, Petr Bob, Ashley Datta   +3 more
doaj   +2 more sources

Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study

Frontiers in Pharmacology, 2020
More than 300 million people suffer from depressive disorders globally. People under early-life stress (ELS) are reportedly vulnerable to depression in their adulthood, and synaptic plasticity can be the molecular mechanism underlying such depression ...
Yongfei Cui, Kerun Cao, Huiyuan Lin, Sainan Cui, Chongkun Shen, Wenhao Wen, Haixin Mo, Zhaoyang Dong, Shasha Bai, Lei Yang, Yafei Shi, Rong Zhang   +11 more
doaj   +2 more sources

Effects of Early-Life Stress on the Brain and Behaviors: Implications of Early Maternal Separation in Rodents [PDF]

International Journal of Molecular Sciences, 2020
Early-life stress during the prenatal and postnatal periods affects the formation of neural networks that influence brain function throughout life. Previous studies have indicated that maternal separation (MS), a typical rodent model equivalent to early ...
Mayumi Nishi
openalex   +2 more sources

Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation. [PDF]

Microbiome
Background Intestinal microbial composition not only affects the health of the gut but also influences centrally mediated systems involved in mood, through the “gut-brain” axis, a bidirectional communication between gut microbiota and the brain.
De Santa F, Strimpakos G, Marchetti N, Gargari G, Torcinaro A, Arioli S, Mora D, Petrella C, Farioli-Vecchioli S.   +8 more
europepmc   +2 more sources

Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice. [PDF]

PLoS ONE, 2016
Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still developing.
Irene Gracia-Rubio, Elena Martinez-Laorden, Maria Moscoso-Castro, M Victoria Milanés, M Luisa Laorden, Olga Valverde   +5 more
doaj   +3 more sources