Dissociative symptoms in school-aged adopted children who experienced maternal separation and disruptive caregiving in infancy [PDF]
Frontiers in PsychiatryAmounting findings on maternal separation and early disturbed caregiving suggest that this type of early experience negatively influences socioemotional development and may be associated with behavioral and mental health problems in later life ...
Petra Winnette +3 more
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The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice [PDF]
Frontiers in Molecular Neuroscience, 2023 Neonatal maternal separation is a widely used method to construct an early-life stress model in rodents. In this method, pups are separated from their mothers for several hours every day during the first 2 weeks of life, which results in adverse early ...
Sangyep Shin, Sukwon Lee
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Developmental Cognitive Neuroscience, 2022 Adverse early life experiences, such as maternal separation, are associated with an increased risk for several mental health problems. Symptoms induced by maternal separation that mirror clinically relevant aspects of mental problems, such as cognitive ...
Bo Ou-Yang +6 more
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Frontiers in Behavioral Neuroscience, 2021 Maternal separation has been shown to disrupt proper brain development and maturation, having profound consequences on the neuroendocrine systems in charge of the stress response, and has been shown to induce behavioral and cognitive abnormalities.
Sara Mejía-Chávez +4 more
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Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats. [PDF]
PLoS ONE, 2016 Early-life stress is associated with depression and metabolic abnormalities that increase the risk of cardiovascular disease and diabetes. Such associations could be due to increased glucocorticoid levels.
Javier Vargas +3 more
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Targeting the Stress System During Gestation: Is Early Handling a Protective Strategy for the Offspring? [PDF]
, 2020 The perinatal window is a critical developmental time when abnormal gestational stimuli may alter the development of the stress system that, in turn, influences behavioral and physiological responses in the newborns.
Brancato, Anna +3 more
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Epigenetic upregulation of corticotrophin-releasing hormone mediates postnatal maternal separation-induced memory deficiency. [PDF]
PLoS ONE, 2014 Accumulating evidences demonstrated that early postnatal maternal separation induced remarkable social and memory defects in the adult rodents. Early-life stress induced long-lasting functional adaptation of neuroendocrine hypothalamic-pituitary-adrenal ...
Aiyun Wang +6 more
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Examining the Factorial Structure of the Maternal Separation Anxiety Scale in a Portuguese Sample
Frontiers in Psychology, 2021 The increase in women’s labor market participation emphasizes the importance of understanding maternal separation anxiety, that is, the unpleasant maternal emotional state, due to the actual or anticipated short-term separation from the child. Drawing on
Maryse Guedes +4 more
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Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice. [PDF]
PLoS ONE, 2016 Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still developing.
Irene Gracia-Rubio +5 more
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IBRO Neuroscience Reports, 2022 Environmental stimuli in early life are recognized to affect brain development and behavior. Mother-pup interaction constitutes a determinant stimulus during this critical period.
Ada Sinani +5 more
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