Results 51 to 60 of about 9,281 (250)
Pharmaceutical Science AdvancesMatrine is the main component extracted from legumes and has extensive anti-cancer effects; however, its molecular mechanism is unclear. In our study, we found that matrine induced vacuolation in leukemia cells is closely related to cell proliferation ...
Fanfan Yang +5 more
doaj +1 more source
Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents
Molecules, 2022 Matrine derivatives were reported to have various biological activities, especially the ester, amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at the end of the branch chain after the D ring of matrine is opened ...
Wanjun Ni +4 more
doaj +1 more source
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]
, 2020 BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai +10 more
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International Journal of Molecular SciencesMatrine (MT) possesses anti-inflammatory, anti-allergic and antioxidative properties. However, the impact and underlying mechanisms of matrine on colitis are unclear.
Ningning Mao +6 more
semanticscholar +1 more source
Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Drug Design, Development and Therapy, 2022 As The main effective monomer of the traditional Chinese medicine Sophora flavescens Ait, matrine has a broad scope of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral, anti-arrhythmia, and improving ...
Ying-Liang Lin +4 more
semanticscholar +1 more source
Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats [PDF]
, 2014 OBJECTIVE: To describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase (ATGL) and G0/G1 switch gene 2 (G0S2) in adipose tissue of diet-induced obese rats.
Changhui Wang +14 more
core +1 more source
Cancer Cell International, 2020 Background Matrine has been reported to exert anti-tumor effects in multiple types of cancers containing hepatocellular carcinoma (HCC). However, the anti-tumor molecular mechanisms of matrine in HCC is still not fully revealed.
Shaobing Lin +3 more
doaj +1 more source
Molecular mechanisms of cell death induced by matrine in human cholangiocarcinoma Cells [PDF]
, 2016 胆管癌是起源于胆管上皮的一种恶性肿瘤，在我国发病率和死亡率逐年上升。而胆管癌细胞抵抗凋亡是导致胆管癌化疗失败的重要原因，所以研发能够诱导胆管癌细胞以不发生凋亡的死亡新途径的化疗药显得十分重要。苦参碱具有多途径、多种机制的抗肿瘤活性，已经证实能够诱导多种肿瘤细胞死亡，但是在胆管癌中的生物学作用和潜在机制却鲜有报道。程序性坏死(necroptosis)是可被调控的程序性细胞死亡，在形态学上具有典型的坏死样形态改变，依赖于受体相互作用蛋白1和3，此外，可被程序性坏死的特异性抑制剂Nec-1所阻断 ...
徐贝贝
core
Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review. [PDF]
, 2017 Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases.
Asadi-Samani, Majid. +3 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen +7 more
wiley +1 more source