Results 141 to 150 of about 4,103 (166)

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

Cell, 2022
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear. Here, we investigated the effects of APOE4 on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice ...
Minghui Wang, Yang Shi, Alison Goate
exaly   +5 more sources

The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer [PDF]

Cancers, 2022
The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment.
Jae-Ho Cheong, Ji-Yong Sung
exaly   +3 more sources

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Citrullination of matrisomal proteins in health and diseases

Philosophical Transactions of the Royal Society B: Biological Sciences, 2023
Proteins once translated are subjected to post-translational modifications (PTMs) that can critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed by peptidylarginine deiminase (PAD) enzymes, which regulate a multitude of physiological functions such as apoptosis, gene expression and immune response by altering
Mohammad Aslam Saifi, I-Cheng Ho
openaire   +2 more sources

Beyond the matrisome: New frontiers in ECM research

Matrix Biology, 2023
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Suneel S, Apte, Alexandra, Naba
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NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression

Cancer Research, 2022
Abstract Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinductive effects, yet it is highly expressed in ...
Qizhi Qin, Mario Gomez-Salazar, Robert J. Tower, Leslie Chang, Carol D. Morris, Edward F. McCarthy, Kang Ting, Xinli Zhang, Aaron W. James   +8 more
openaire   +2 more sources

The “Matrisome” reveals the characterization of skin keloid microenvironment

The FASEB Journal, 2021
Abstract Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis.
Shikun Zhang, Binghui Liu, Wenjuan Wang, Luye Lv, Dunqin Gao, Mi Chai, Mansheng Li, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng   +10 more
openaire   +2 more sources

Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome

2020
The tumor matrisome, the collection of structural and functional extracellular matrix (ECM) proteins found in tumors together with ECM-associated proteins, growth factors, cytokines and chemokines is an extremely dynamic entity whose composition and regulation depends on both local, cell-specific processes and overarching pan-cancer microenvironmental ...
Valerio Izzi, Jarkko Koivunen, Pekka Rappu, Jyrki Heino, Taina Pihlajaniemi   +4 more
openaire   +2 more sources

Striosomes and Matrisomes

1991
In the past twelve years it has become clear that most neurotransmitter systems in the striatum are differentially distributed with respect to striosomes (“striatal bodies”) and their surrounding extrastriosomal matrix (Graybiel and Ragsdale, 1978, 1983; Herkenham and Pert, 1981; Gerfen, 1984; Gerfen et al., 1985a).
A. M. Graybiel, A. W. Flaherty, J.-M. Giménez-Amaya   +2 more
openaire   +1 more source

A matrisome atlas of germ cell development

2023
Abstract The extracellular matrix (matrisome) provides chemical and mechanical cues to control the structure and function of cells and tissues. Yet, comprehensive understanding of how matrisome factors individually and collectively control cell and tissue behavior in vivo is lacking.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
openaire   +1 more source

Senescence-Associated Alterations in Matrisome of Mesenchymal Stem Cells

International Journal of Molecular Sciences
The process of aging is intimately linked to alterations at the tissue and cellular levels. Currently, the role of senescent cells in the tissue microenvironment is still being investigated. Despite common characteristics, different cell populations undergo distinctive morphofunctional changes during senescence.
Ludmila Buravkova, Mariia Ezdakova, Diana Matveeva   +2 more
exaly   +3 more sources