Results 141 to 150 of about 5,280 (176)
A Single-Step Protein Extraction for Lung Extracellular Matrix Proteomics Enabled by the Photocleavable Surfactant Azo and timsTOF Pro. [PDF]
Mol Cell ProteomicsTowler AG +9 more
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Pan-cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors. [PDF]
Int J CancerTang G +6 more
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Matrisome changes in Parkinson’s disease
Analytical and Bioanalytical Chemistry, 2022Extracellular matrix (ECM) proteins, collectively known as the matrisome, include collagens, glycoproteins, and proteoglycans. Alterations in the matrisome have been implicated in the neurodegenerative pathologies including Parkinson's disease (PD). In this work, we utilized our previously published PD and control proteomics data from human prefrontal ...
Margaret Downs +2 more
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Degradomics technologies in matrisome exploration
Matrix Biology, 2022 Consisting of a defined set of extracellular proteins secreted from resident cells and with minor contributions from serum proteins, the extracellular matrix (ECM) is an essential component of all tissues. Maintaining tissue homeostasis, structural support and cellular control through cell-ECM communication, the ECM has come to be viewed as not just a ...
Ulrich auf dem Keller
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Microgravity Effects on the Matrisome [PDF]
Cells, 2021 Gravity is fundamental factor determining all processes of development and vital activity on Earth. During evolution, a complex mechanism of response to gravity alterations was formed in multicellular organisms. It includes the “gravisensors” in extracellular and intracellular spaces.
Ludmila B Buravkova
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Cell, 2022 The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear. Here, we investigated the effects of APOE4 on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice ...
Julia Tcw, Nina H Pipalia, Yang Shi
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NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Cancer Research, 2022Abstract Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinductive effects, yet it is highly expressed in ...
Qizhi Qin +8 more
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Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome
2020The tumor matrisome, the collection of structural and functional extracellular matrix (ECM) proteins found in tumors together with ECM-associated proteins, growth factors, cytokines and chemokines is an extremely dynamic entity whose composition and regulation depends on both local, cell-specific processes and overarching pan-cancer microenvironmental ...
Valerio Izzi +4 more
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Citrullination of matrisomal proteins in health and diseases
Philosophical Transactions of the Royal Society B: Biological Sciences, 2023Proteins once translated are subjected to post-translational modifications (PTMs) that can critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed by peptidylarginine deiminase (PAD) enzymes, which regulate a multitude of physiological functions such as apoptosis, gene expression and immune response by altering
Mohammad Aslam Saifi, I-Cheng Ho
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1991
In the past twelve years it has become clear that most neurotransmitter systems in the striatum are differentially distributed with respect to striosomes (“striatal bodies”) and their surrounding extrastriosomal matrix (Graybiel and Ragsdale, 1978, 1983; Herkenham and Pert, 1981; Gerfen, 1984; Gerfen et al., 1985a).
A. M. Graybiel +2 more
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In the past twelve years it has become clear that most neurotransmitter systems in the striatum are differentially distributed with respect to striosomes (“striatal bodies”) and their surrounding extrastriosomal matrix (Graybiel and Ragsdale, 1978, 1983; Herkenham and Pert, 1981; Gerfen, 1984; Gerfen et al., 1985a).
A. M. Graybiel +2 more
openaire +1 more source